The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts.
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| Title: | The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. |
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| Authors: | Gosso, M. F., de Geus, E. J. C., van Belzen, M. J., Polderman, T. J. C., Heutink, P., Boomsma, D. I., Posthuma, D. |
| Source: | Molecular Psychiatry. Sep2006, Vol. 11 Issue 9, p878-886. 9p. 6 Charts, 2 Graphs. |
| Subjects: | Genetics, Genes, Intellect, Genetic polymorphisms, Neocortex, Hippocampus (Brain) |
| Abstract: | The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12–20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.Molecular Psychiatry (2006) 11, 878–886. doi:10.1038/sj.mp.4001868; published online 27 June 2006 [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 22111542 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gosso%2C+M%2E+F%2E%22">Gosso, M. F.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Geus%2C+E%2E+J%2E+C%2E%22">de Geus, E. J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Belzen%2C+M%2E+J%2E%22">van Belzen, M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Polderman%2C+T%2E+J%2E+C%2E%22">Polderman, T. J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Heutink%2C+P%2E%22">Heutink, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Boomsma%2C+D%2E+I%2E%22">Boomsma, D. I.</searchLink><br /><searchLink fieldCode="AR" term="%22Posthuma%2C+D%2E%22">Posthuma, D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Sep2006, Vol. 11 Issue 9, p878-886. 9p. 6 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Intellect%22">Intellect</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Neocortex%22">Neocortex</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human intelligence. In two independent family-based Dutch samples of 391 (mean age 12.4 years) and 276 (mean age 37.3 years) subjects, respectively, we genotyped 12 single-nucleotide polymorphisms (SNPs) in the SNAP-25 gene on 20p12–20p11.2. From all individuals, standardized intelligence measures were available. Using a family-based association test, a strong association was found between three SNPs in the SNAP-25 gene and intelligence, two of which showed association in both independent samples. The strongest, replicated association was found between SNP rs363050 and performance IQ (PIQ), where the A allele was associated with an increase of 2.84 PIQ points (P=0.0002). Variance in this SNP accounts for 3.4 % of the phenotypic variance in PIQ.Molecular Psychiatry (2006) 11, 878–886. doi:10.1038/sj.mp.4001868; published online 27 June 2006 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4001868 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 878 Subjects: – SubjectFull: Genetics Type: general – SubjectFull: Genes Type: general – SubjectFull: Intellect Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Neocortex Type: general – SubjectFull: Hippocampus (Brain) Type: general Titles: – TitleFull: The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gosso, M. F. – PersonEntity: Name: NameFull: de Geus, E. J. C. – PersonEntity: Name: NameFull: van Belzen, M. J. – PersonEntity: Name: NameFull: Polderman, T. J. C. – PersonEntity: Name: NameFull: Heutink, P. – PersonEntity: Name: NameFull: Boomsma, D. I. – PersonEntity: Name: NameFull: Posthuma, D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 11 – Type: issue Value: 9 Titles: – TitleFull: Molecular Psychiatry Type: main |
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