Elevation of plasma concentration of adhesion molecules in late-life depression.
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| Title: | Elevation of plasma concentration of adhesion molecules in late-life depression. |
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| Authors: | Dimopoulos, Nikolaos, Piperi, Christina, Salonicioti, Aristea, Mitsonis, Charalampos, Liappas, Ioannis, Lea, Robert W., Kalofoutis, Anastasios |
| Source: | International Journal of Geriatric Psychiatry. Oct2006, Vol. 21 Issue 10, p965-971. 7p. 1 Chart, 1 Graph. |
| Subjects: | Cell adhesion molecules, Blood plasma, Mental depression, Vascular diseases, Blood circulation disorders |
| Abstract: | Objectives Late-life depression may be associated with vascular disease. The purpose of the study was to investigate this association by determining the levels of soluble adhesion molecules (sICAM-1 and sVCAM-1) which represent markers of ischemia-induced inflammation in elderly individuals with depression. Methods Blood samples were obtained from 33 subjects with depression selected from a community-dwelling population after screening with the Geriatric Depression Scale, and 33 matched controls. Serum concentrations of sICAM-1 (ng/mL) and sVCAM-1 (ng/mL) were measured in both groups. Results Depressed patients (Group A) possessed significantly higher sICAM-1 levels compared to healthy controls (Group B) (674.94 ± 166.90 ng/ml vs 467.05 ± 231.26 ng/ml, respectively, p < 0.01). Similarly the same groups demonstrated elevated sVCAM-1 levels compared to controls (572.14 ± 182.20 ng/ml vs 449.04 ± 285.27 ng/ml, p < 0.05); a difference that in both cases remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Conclusion These findings indicate an association between high serum levels of VCAM-1, and ICAM-1 and depression in the elderly and further support the vascular depression hypothesis, which has important implications for the understanding and management of late-life depression. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 22524256 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Elevation of plasma concentration of adhesion molecules in late-life depression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dimopoulos%2C+Nikolaos%22">Dimopoulos, Nikolaos</searchLink><br /><searchLink fieldCode="AR" term="%22Piperi%2C+Christina%22">Piperi, Christina</searchLink><br /><searchLink fieldCode="AR" term="%22Salonicioti%2C+Aristea%22">Salonicioti, Aristea</searchLink><br /><searchLink fieldCode="AR" term="%22Mitsonis%2C+Charalampos%22">Mitsonis, Charalampos</searchLink><br /><searchLink fieldCode="AR" term="%22Liappas%2C+Ioannis%22">Liappas, Ioannis</searchLink><br /><searchLink fieldCode="AR" term="%22Lea%2C+Robert+W%2E%22">Lea, Robert W.</searchLink><br /><searchLink fieldCode="AR" term="%22Kalofoutis%2C+Anastasios%22">Kalofoutis, Anastasios</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Oct2006, Vol. 21 Issue 10, p965-971. 7p. 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cell+adhesion+molecules%22">Cell adhesion molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+diseases%22">Vascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+circulation+disorders%22">Blood circulation disorders</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives Late-life depression may be associated with vascular disease. The purpose of the study was to investigate this association by determining the levels of soluble adhesion molecules (sICAM-1 and sVCAM-1) which represent markers of ischemia-induced inflammation in elderly individuals with depression. Methods Blood samples were obtained from 33 subjects with depression selected from a community-dwelling population after screening with the Geriatric Depression Scale, and 33 matched controls. Serum concentrations of sICAM-1 (ng/mL) and sVCAM-1 (ng/mL) were measured in both groups. Results Depressed patients (Group A) possessed significantly higher sICAM-1 levels compared to healthy controls (Group B) (674.94 ± 166.90 ng/ml vs 467.05 ± 231.26 ng/ml, respectively, p < 0.01). Similarly the same groups demonstrated elevated sVCAM-1 levels compared to controls (572.14 ± 182.20 ng/ml vs 449.04 ± 285.27 ng/ml, p < 0.05); a difference that in both cases remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Conclusion These findings indicate an association between high serum levels of VCAM-1, and ICAM-1 and depression in the elderly and further support the vascular depression hypothesis, which has important implications for the understanding and management of late-life depression. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/gps.1592 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 965 Subjects: – SubjectFull: Cell adhesion molecules Type: general – SubjectFull: Blood plasma Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Vascular diseases Type: general – SubjectFull: Blood circulation disorders Type: general Titles: – TitleFull: Elevation of plasma concentration of adhesion molecules in late-life depression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dimopoulos, Nikolaos – PersonEntity: Name: NameFull: Piperi, Christina – PersonEntity: Name: NameFull: Salonicioti, Aristea – PersonEntity: Name: NameFull: Mitsonis, Charalampos – PersonEntity: Name: NameFull: Liappas, Ioannis – PersonEntity: Name: NameFull: Lea, Robert W. – PersonEntity: Name: NameFull: Kalofoutis, Anastasios IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 08856230 Numbering: – Type: volume Value: 21 – Type: issue Value: 10 Titles: – TitleFull: International Journal of Geriatric Psychiatry Type: main |
| ResultId | 1 |
