Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze.
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| Title: | Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze. |
|---|---|
| Authors: | Restivo, L., Chaillan, F. A., Ammassari-Teule, M., Roman, F. S., Marchetti, E. |
| Source: | Behavior Genetics. Nov2006, Vol. 36 Issue 6, p923-934. 12p. 1 Black and White Photograph, 5 Graphs. |
| Subjects: | Learning disability genetics, Memory, Transgenic mice, Gene targeting, Behavior genetics, Olfactory cortex, Genetics |
| Abstract: | We trained BALB/c Byllco (C), CD-1, SV 129/SvPasCr1 (129 SV), C57BL/6 (B6) and DBA/2J (D2) mice using the olfactory tubing maze with the hope of gaining insight into behavioral genetics related to learning and memory processes. All strains of mice acquired the odor–reward associations using this new task except the D2 strain. The C, CD-1, and 129 SV consistently remembered the associations from the sixth 20-trial training session, reaching 80% ± 5 correct responses in session seven. The B6 mice required one more session to reach 76%, while the D2 mice never learned the correct odor–reward associations. All mice learned the paradigm and the timing of the task, although the 129 SV mice decreased slower the inter-trial intervals across sessions. With this new task, D2 mice, with a deficit totally devoted to an impairment on learning and memory, can be used as a model of hippocampal dysfunction, in some respects like that observed in human amnesic patients whose selective hippocampal-dependent memory is deeply impaired. The high-scoring strains (C, CD-1, and 129 SV) seem to be ideal in this task to study a gene-targeting mutation postulated to reduce behavioral performance, and inversely, for D2 mice. The moderate-scoring strain, B6, should be ideal for allowing gene-targeting to go either way. In addition, this new task, which enables automated training of odor associations, could be used for studying the phenomenon of transitivity in mice, as described in rats. [ABSTRACT FROM AUTHOR] |
| Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 22657576 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Restivo%2C+L%2E%22">Restivo, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Chaillan%2C+F%2E+A%2E%22">Chaillan, F. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ammassari-Teule%2C+M%2E%22">Ammassari-Teule, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Roman%2C+F%2E+S%2E%22">Roman, F. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Marchetti%2C+E%2E%22">Marchetti, E.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Behavior+Genetics%22">Behavior Genetics</searchLink>. Nov2006, Vol. 36 Issue 6, p923-934. 12p. 1 Black and White Photograph, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Learning+disability+genetics%22">Learning disability genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Transgenic+mice%22">Transgenic mice</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+targeting%22">Gene targeting</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+genetics%22">Behavior genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Olfactory+cortex%22">Olfactory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We trained BALB/c Byllco (C), CD-1, SV 129/SvPasCr1 (129 SV), C57BL/6 (B6) and DBA/2J (D2) mice using the olfactory tubing maze with the hope of gaining insight into behavioral genetics related to learning and memory processes. All strains of mice acquired the odor–reward associations using this new task except the D2 strain. The C, CD-1, and 129 SV consistently remembered the associations from the sixth 20-trial training session, reaching 80% ± 5 correct responses in session seven. The B6 mice required one more session to reach 76%, while the D2 mice never learned the correct odor–reward associations. All mice learned the paradigm and the timing of the task, although the 129 SV mice decreased slower the inter-trial intervals across sessions. With this new task, D2 mice, with a deficit totally devoted to an impairment on learning and memory, can be used as a model of hippocampal dysfunction, in some respects like that observed in human amnesic patients whose selective hippocampal-dependent memory is deeply impaired. The high-scoring strains (C, CD-1, and 129 SV) seem to be ideal in this task to study a gene-targeting mutation postulated to reduce behavioral performance, and inversely, for D2 mice. The moderate-scoring strain, B6, should be ideal for allowing gene-targeting to go either way. In addition, this new task, which enables automated training of odor associations, could be used for studying the phenomenon of transitivity in mice, as described in rats. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10519-006-9088-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 923 Subjects: – SubjectFull: Learning disability genetics Type: general – SubjectFull: Memory Type: general – SubjectFull: Transgenic mice Type: general – SubjectFull: Gene targeting Type: general – SubjectFull: Behavior genetics Type: general – SubjectFull: Olfactory cortex Type: general – SubjectFull: Genetics Type: general Titles: – TitleFull: Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Restivo, L. – PersonEntity: Name: NameFull: Chaillan, F. A. – PersonEntity: Name: NameFull: Ammassari-Teule, M. – PersonEntity: Name: NameFull: Roman, F. S. – PersonEntity: Name: NameFull: Marchetti, E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00018244 Numbering: – Type: volume Value: 36 – Type: issue Value: 6 Titles: – TitleFull: Behavior Genetics Type: main |
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