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Reward-related decision-making in pediatric major depressive disorder: an fMRI study.

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Title: Reward-related decision-making in pediatric major depressive disorder: an fMRI study.
Authors: Forbes, Erika E. (AUTHOR), Christopher May, J. (AUTHOR), Siegle, Greg J. (AUTHOR), Ladouceur, Cecile D. (AUTHOR), Ryan, Neal D. (AUTHOR), Carter, Cameron S. (AUTHOR), Birmaher, Boris (AUTHOR), Axelson, David A. (AUTHOR), Dahl, Ronald E. (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Oct2006, Vol. 47 Issue 10, p1031-1040. 10p. 1 Diagram, 3 Charts, 1 Graph.
Subjects: Magnetic resonance imaging of the brain, Reward (Psychology), Decision making, Affective disorders, Depression in adolescence, Motivation (Psychology), Anxiety disorders, Patients
Abstract: Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9–17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Reward-related decision-making in pediatric major depressive disorder: an fMRI study.
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  Data: <searchLink fieldCode="AR" term="%22Forbes%2C+Erika+E%2E%22">Forbes, Erika E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Christopher+May%2C+J%2E%22">Christopher May, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Siegle%2C+Greg+J%2E%22">Siegle, Greg J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ladouceur%2C+Cecile+D%2E%22">Ladouceur, Cecile D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ryan%2C+Neal+D%2E%22">Ryan, Neal D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carter%2C+Cameron+S%2E%22">Carter, Cameron S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birmaher%2C+Boris%22">Birmaher, Boris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Axelson%2C+David+A%2E%22">Axelson, David A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dahl%2C+Ronald+E%2E%22">Dahl, Ronald E.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Oct2006, Vol. 47 Issue 10, p1031-1040. 10p. 1 Diagram, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging+of+the+brain%22">Magnetic resonance imaging of the brain</searchLink><br /><searchLink fieldCode="DE" term="%22Reward+%28Psychology%29%22">Reward (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Decision+making%22">Decision making</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+in+adolescence%22">Depression in adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Motivation+%28Psychology%29%22">Motivation (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9–17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1469-7610.2006.01673.x
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              Text: Oct2006
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