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Pure progressive amnesia: An atypical amnestic syndrome?

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Title: Pure progressive amnesia: An atypical amnestic syndrome?
Authors: Barbeau, EmmanuelJ. (AUTHOR), Didic, Mira (AUTHOR), Felician, Olivier (AUTHOR), Tramoni, Eve (AUTHOR), Guedj, Eric (AUTHOR), Ceccaldi, Mathieu (AUTHOR), Poncet, Michel (AUTHOR)
Source: Cognitive Neuropsychology. Dec2006, Vol. 23 Issue 8, p1230-1247. 18p. 1 Diagram, 6 Charts, 4 Graphs.
Subjects: Amnesia, Progressive supranuclear palsy, Transient global amnesia, Alzheimer's disease, Korsakoff's syndrome, Neuropsychological tests, Explicit memory, Cognitive neuroscience
Abstract: We report on M.S., an 83-year-old patient with isolated pure progressive amnesia. This rare, recently identified, form of amnesia has been described in elderly patients. Neuropathological studies suggest that this syndrome is an atypical clinical presentation of Alzheimer's disease. The aim of our study was to characterize the neuropsychological pattern of pure progressive amnesia in comparison with other amnestic syndromes and memory dissociations reported in the literature. Our results indicate that pure progressive amnesia is characterized by a highly unusual dissociation in the realm of memory, with severe deficits on tests based on recognition and recall of verbal and visual single items, contrasting with relatively preserved anterograde autobiographical and spatial memory and normal recall of complex material such as stories. These findings suggest that memory for single items could depend on an independent system. One hypothesis is that M.S.'s unusual memory profile results from relative dysfunction of the ventral medial temporal lobe pathway. An alternative explanation implicates cognitive reserve. Further studies are required in order to progress on this matter. In any case, pure progressive amnesia is a clinical syndrome that may provide further insight into the organization of declarative memory. [ABSTRACT FROM AUTHOR]
Copyright of Cognitive Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="JN" term="%22Cognitive+Neuropsychology%22">Cognitive Neuropsychology</searchLink>. Dec2006, Vol. 23 Issue 8, p1230-1247. 18p. 1 Diagram, 6 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Amnesia%22">Amnesia</searchLink><br /><searchLink fieldCode="DE" term="%22Progressive+supranuclear+palsy%22">Progressive supranuclear palsy</searchLink><br /><searchLink fieldCode="DE" term="%22Transient+global+amnesia%22">Transient global amnesia</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Korsakoff's+syndrome%22">Korsakoff's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Explicit+memory%22">Explicit memory</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+neuroscience%22">Cognitive neuroscience</searchLink>
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  Data: We report on M.S., an 83-year-old patient with isolated pure progressive amnesia. This rare, recently identified, form of amnesia has been described in elderly patients. Neuropathological studies suggest that this syndrome is an atypical clinical presentation of Alzheimer's disease. The aim of our study was to characterize the neuropsychological pattern of pure progressive amnesia in comparison with other amnestic syndromes and memory dissociations reported in the literature. Our results indicate that pure progressive amnesia is characterized by a highly unusual dissociation in the realm of memory, with severe deficits on tests based on recognition and recall of verbal and visual single items, contrasting with relatively preserved anterograde autobiographical and spatial memory and normal recall of complex material such as stories. These findings suggest that memory for single items could depend on an independent system. One hypothesis is that M.S.'s unusual memory profile results from relative dysfunction of the ventral medial temporal lobe pathway. An alternative explanation implicates cognitive reserve. Further studies are required in order to progress on this matter. In any case, pure progressive amnesia is a clinical syndrome that may provide further insight into the organization of declarative memory. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Cognitive Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Pure progressive amnesia: An atypical amnestic syndrome?
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              Text: Dec2006
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