Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep.
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| Title: | Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep. |
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| Authors: | Nuñez, A. (AUTHOR), Moreno‐Balandrán, M. E. (AUTHOR), Rodrigo‐Angulo, M. L. (AUTHOR), Garzón, M. (AUTHOR), De Andrés, I. (AUTHOR) |
| Source: | European Journal of Neuroscience. Nov2006, Vol. 24 Issue 10, p2834-2842. 9p. 1 Diagram, 1 Chart, 3 Graphs. |
| Subjects: | Rapid eye movement sleep, Hypothalamus, Rats, Orexins, Neurons, Microelectrodes, Micropipettes, Electric stimulation |
| Abstract: | The perifornical (PeF) area in the posterior lateral hypothalamus has been implicated in several physiological functions including the regulation of sleep–wakefulness. Some PeF neurons, which contain hypocretin, have been suggested to play an important role in sleep–wake regulation. The aim of the present study was to examine the effect of the PeF area and hypocretin on the electrophysiological activity of neurons of the oral pontine reticular nucleus (PnO), which is an important structure in the generation and maintenance of rapid eye movement sleep. PnO neurons were recorded in urethane-anesthetized rats. Extracellular recordings were performed by means of tungsten microelectrodes or barrel micropipettes. Electrical stimulation of the ipsilateral PeF area elicited orthodromic responses in both type I (49%) and type II (58%) electrophysiologically characterized PnO neurons, with a mean latency of 13.0 ± 2 and 8.3 ± 5 ms, respectively. In six cases, antidromic spikes were evoked in type I PnO neurons with a mean latency of 3.2 ± 0.4 ms, indicating the existence of PnO neurons that projected to the PeF area. Anatomical studies showed retrogradely labeled neurons in the PeF area from the PnO. Some of these neurons projecting to the PnO contained hypocretin (17.8%). Iontophoretic application of hypocretin-1 through a barrel micropipette in the PnO induced an inhibition, which was blocked by a previous iontophoretic application of bicuculline, indicating that the inhibitory action of hypocretin-1 may be due to activation of GABAA receptors. These data suggest that the PeF area may control the generation of rapid eye movement sleep through a hypocretinergic projection by inhibiting the activity of PnO neurons. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 23216579 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nuñez%2C+A%2E%22">Nuñez, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreno‐Balandrán%2C+M%2E+E%2E%22">Moreno‐Balandrán, M. E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigo‐Angulo%2C+M%2E+L%2E%22">Rodrigo‐Angulo, M. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garzón%2C+M%2E%22">Garzón, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Andrés%2C+I%2E%22">De Andrés, I.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2006, Vol. 24 Issue 10, p2834-2842. 9p. 1 Diagram, 1 Chart, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Rapid+eye+movement+sleep%22">Rapid eye movement sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Hypothalamus%22">Hypothalamus</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Orexins%22">Orexins</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Microelectrodes%22">Microelectrodes</searchLink><br /><searchLink fieldCode="DE" term="%22Micropipettes%22">Micropipettes</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The perifornical (PeF) area in the posterior lateral hypothalamus has been implicated in several physiological functions including the regulation of sleep–wakefulness. Some PeF neurons, which contain hypocretin, have been suggested to play an important role in sleep–wake regulation. The aim of the present study was to examine the effect of the PeF area and hypocretin on the electrophysiological activity of neurons of the oral pontine reticular nucleus (PnO), which is an important structure in the generation and maintenance of rapid eye movement sleep. PnO neurons were recorded in urethane-anesthetized rats. Extracellular recordings were performed by means of tungsten microelectrodes or barrel micropipettes. Electrical stimulation of the ipsilateral PeF area elicited orthodromic responses in both type I (49%) and type II (58%) electrophysiologically characterized PnO neurons, with a mean latency of 13.0 ± 2 and 8.3 ± 5 ms, respectively. In six cases, antidromic spikes were evoked in type I PnO neurons with a mean latency of 3.2 ± 0.4 ms, indicating the existence of PnO neurons that projected to the PeF area. Anatomical studies showed retrogradely labeled neurons in the PeF area from the PnO. Some of these neurons projecting to the PnO contained hypocretin (17.8%). Iontophoretic application of hypocretin-1 through a barrel micropipette in the PnO induced an inhibition, which was blocked by a previous iontophoretic application of bicuculline, indicating that the inhibitory action of hypocretin-1 may be due to activation of GABAA receptors. These data suggest that the PeF area may control the generation of rapid eye movement sleep through a hypocretinergic projection by inhibiting the activity of PnO neurons. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1460-9568.2006.05159.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 2834 Subjects: – SubjectFull: Rapid eye movement sleep Type: general – SubjectFull: Hypothalamus Type: general – SubjectFull: Rats Type: general – SubjectFull: Orexins Type: general – SubjectFull: Neurons Type: general – SubjectFull: Microelectrodes Type: general – SubjectFull: Micropipettes Type: general – SubjectFull: Electric stimulation Type: general Titles: – TitleFull: Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nuñez, A. – PersonEntity: Name: NameFull: Moreno‐Balandrán, M. E. – PersonEntity: Name: NameFull: Rodrigo‐Angulo, M. L. – PersonEntity: Name: NameFull: Garzón, M. – PersonEntity: Name: NameFull: De Andrés, I. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 24 – Type: issue Value: 10 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
