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Leukoencephalopathy as a rare complication of hepatitis C infection.

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Title: Leukoencephalopathy as a rare complication of hepatitis C infection.
Authors: Buccoliero, R., Gambelli, S., Sicurelli, F., Malandrini, A., Palmeri, S., De Santis, M., Stromillo, M. L., De Stefano, N., Sperduto, A., Musumeci, S. A., Federico, A.
Source: Neurological Sciences. Nov2006, Vol. 27 Issue 5, p360-363. 4p.
Subjects: Hepatic encephalopathy, Hepatitis C treatment, Diseases in older people, Neuropathy, Cryoglobulins, Magnetic resonance imaging
Abstract: We report the case of a 64-year-old female patient with hepatitis C infection (HCV), who developed Sjögren’s disease and sensory peripheral neuropathy. Clinical conditions worsened over three years with central nervous system involvement characterised by transient third cranial nerve paresis and mild selective impairment of attention and memory. Brain magnetic resonance imaging showed diffuse periventricular and lobar white matter hyperintensity. Laboratory findings included mixed cryoglobulinaemia (type II), cryocrit 1.47%, low serum levels of complement C4 and high levels of rheumatoid factor, HCV 1b genotype, high HCV mRNA levels in serum and cerebrospinal fluid. Skin biopsy showed evidence of vasculitis. After one year of plasmapheresis, immunosuppressant therapy and occasional corticosteroid treatment, neurological symptoms improved, skin biopsy changed and inflammation parameters normalised, suggesting that neurological symptoms might be related to the high levels of mixed cryoglobulins. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Buccoliero%2C+R%2E%22">Buccoliero, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Gambelli%2C+S%2E%22">Gambelli, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sicurelli%2C+F%2E%22">Sicurelli, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Malandrini%2C+A%2E%22">Malandrini, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Palmeri%2C+S%2E%22">Palmeri, S.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Santis%2C+M%2E%22">De Santis, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Stromillo%2C+M%2E+L%2E%22">Stromillo, M. L.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Stefano%2C+N%2E%22">De Stefano, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Sperduto%2C+A%2E%22">Sperduto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Musumeci%2C+S%2E+A%2E%22">Musumeci, S. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Federico%2C+A%2E%22">Federico, A.</searchLink>
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  Data: We report the case of a 64-year-old female patient with hepatitis C infection (HCV), who developed Sjögren’s disease and sensory peripheral neuropathy. Clinical conditions worsened over three years with central nervous system involvement characterised by transient third cranial nerve paresis and mild selective impairment of attention and memory. Brain magnetic resonance imaging showed diffuse periventricular and lobar white matter hyperintensity. Laboratory findings included mixed cryoglobulinaemia (type II), cryocrit 1.47%, low serum levels of complement C4 and high levels of rheumatoid factor, HCV 1b genotype, high HCV mRNA levels in serum and cerebrospinal fluid. Skin biopsy showed evidence of vasculitis. After one year of plasmapheresis, immunosuppressant therapy and occasional corticosteroid treatment, neurological symptoms improved, skin biopsy changed and inflammation parameters normalised, suggesting that neurological symptoms might be related to the high levels of mixed cryoglobulins. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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