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Post-malaria neurological syndrome: clinical and laboratory findings in one patient.

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Title: Post-malaria neurological syndrome: clinical and laboratory findings in one patient.
Authors: Zambito Marsala, S., Ferracci, F., Cecotti, L., Gentile, M., Conte, F., Candeago, R. M., Marchini, C.
Source: Neurological Sciences. Dec2006, Vol. 27 Issue 6, p442-444. 3p.
Subjects: Malaria, Plasmodium falciparum, Hepatic encephalopathy, Neurologic manifestations of general diseases, Clinical trials, Clinical medicine research
Abstract: Post-malaria neurological syndrome (PMNS) is a rare complication of malaria. It follows recovery from an episode of Plasmodium falciparum malaria and is characterised by symptoms and signs of encephalopathy. Patients usually improve without any specific treatment. The pathogenesis is unknown, but it is probably immunologically mediated. The objective of this case study is to describe the first Italian patient with PMNS. A 60-year-old Italian man developed acute P. falciparum malaria after a stay in French Guinea. Twenty days after recovering from malaria, he became confused, developed generalised weakness, limb tremors, shivering and dizziness. These symptoms continued for three days, then resolved spontaneously. Neuroimaging was normal. Cerebrospinal fluid analysis revealed breakdown of the blood/brain barrier, without oligoclonal bands and normal IgG index. Our patient presented a mild diffuse encephalopathy suggestive of a generic activation of the immune system without any specific reaction against antigens within the CNS. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: <searchLink fieldCode="AR" term="%22Zambito+Marsala%2C+S%2E%22">Zambito Marsala, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ferracci%2C+F%2E%22">Ferracci, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Cecotti%2C+L%2E%22">Cecotti, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Gentile%2C+M%2E%22">Gentile, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Conte%2C+F%2E%22">Conte, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Candeago%2C+R%2E+M%2E%22">Candeago, R. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Marchini%2C+C%2E%22">Marchini, C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2006, Vol. 27 Issue 6, p442-444. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Malaria%22">Malaria</searchLink><br /><searchLink fieldCode="DE" term="%22Plasmodium+falciparum%22">Plasmodium falciparum</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+encephalopathy%22">Hepatic encephalopathy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic+manifestations+of+general+diseases%22">Neurologic manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+medicine+research%22">Clinical medicine research</searchLink>
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  Data: Post-malaria neurological syndrome (PMNS) is a rare complication of malaria. It follows recovery from an episode of Plasmodium falciparum malaria and is characterised by symptoms and signs of encephalopathy. Patients usually improve without any specific treatment. The pathogenesis is unknown, but it is probably immunologically mediated. The objective of this case study is to describe the first Italian patient with PMNS. A 60-year-old Italian man developed acute P. falciparum malaria after a stay in French Guinea. Twenty days after recovering from malaria, he became confused, developed generalised weakness, limb tremors, shivering and dizziness. These symptoms continued for three days, then resolved spontaneously. Neuroimaging was normal. Cerebrospinal fluid analysis revealed breakdown of the blood/brain barrier, without oligoclonal bands and normal IgG index. Our patient presented a mild diffuse encephalopathy suggestive of a generic activation of the immune system without any specific reaction against antigens within the CNS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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