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Obsessive–compulsive disorder, tics and anxiety in 6-year-old twins.

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Title: Obsessive–compulsive disorder, tics and anxiety in 6-year-old twins.
Authors: DEREK BOLTON, FRÜHLING RIJSDIJK, THOMAS G. O'CONNOR, SEAN PERRIN, THALIA C. ELEY
Source: Psychological Medicine. Jan2007, Vol. 37 Issue 1, p39-48. 10p.
Subjects: Obsessive-compulsive disorder in children, Etiology of diseases, Pathological psychology, Child psychology, Mental health, Neuroses in children, Tic disorders, Anxiety disorders
Abstract: Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders.Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria.Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished.Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 23650840
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PubTypeId: academicJournal
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  Data: Obsessive–compulsive disorder, tics and anxiety in 6-year-old twins.
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  Data: <searchLink fieldCode="AR" term="%22DEREK+BOLTON%22">DEREK BOLTON</searchLink><br /><searchLink fieldCode="AR" term="%22FRÜHLING+RIJSDIJK%22">FRÜHLING RIJSDIJK</searchLink><br /><searchLink fieldCode="AR" term="%22THOMAS+G%2E+O'CONNOR%22">THOMAS G. O'CONNOR</searchLink><br /><searchLink fieldCode="AR" term="%22SEAN+PERRIN%22">SEAN PERRIN</searchLink><br /><searchLink fieldCode="AR" term="%22THALIA+C%2E+ELEY%22">THALIA C. ELEY</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2007, Vol. 37 Issue 1, p39-48. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder+in+children%22">Obsessive-compulsive disorder in children</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Child+psychology%22">Child psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroses+in+children%22">Neuroses in children</searchLink><br /><searchLink fieldCode="DE" term="%22Tic+disorders%22">Tic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders.Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria.Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished.Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=23650840
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        Value: 10.1017/S0033291706008816
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        Text: English
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      – SubjectFull: Etiology of diseases
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              Text: Jan2007
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