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Antidepressants in child and adolescent depression: where are the bugs?

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Title: Antidepressants in child and adolescent depression: where are the bugs?
Authors: Moreno, C. (AUTHOR), Arango, C. (AUTHOR), Parellada, M. (AUTHOR), Shaffer, D. (AUTHOR), Bird, H. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Mar2007, Vol. 115 Issue 3, p184-195. 12p. 1 Chart.
Subjects: Antidepressants, Mental depression, Teenagers, Depression in children, Pediatrics
Abstract: Objective: To examine the data on the effect of antidepressant medication in depressed children and adolescents and the causes of the results obtained. Method: A systematic literature search was conducted, supplemented by a manual search, and a search of public online information on paediatric antidepressant trials reviewed by regulatory agencies. Results: Data gathered from published and unpublished randomized controlled trials vary in their findings, with most of the studies showing a lack of efficacy characterized by a high placebo response rate. Conclusion: Differences from efficacy results with the same drugs in adult depression may be because of neurobiological developmental correlates, developmental differences in pharmacokinetics and pharmacodynamics, high rates of placebo response in children, and a number of methodological influences. There are several areas needing more attention in paediatric antidepressant clinical trials. Judicious use of published and unpublished studies to assess who may benefit from treatment with antidepressants seems warranted. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Antidepressants in child and adolescent depression: where are the bugs?
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  Data: <searchLink fieldCode="AR" term="%22Moreno%2C+C%2E%22">Moreno, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arango%2C+C%2E%22">Arango, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parellada%2C+M%2E%22">Parellada, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shaffer%2C+D%2E%22">Shaffer, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bird%2C+H%2E%22">Bird, H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Mar2007, Vol. 115 Issue 3, p184-195. 12p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Teenagers%22">Teenagers</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+in+children%22">Depression in children</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatrics%22">Pediatrics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To examine the data on the effect of antidepressant medication in depressed children and adolescents and the causes of the results obtained. Method: A systematic literature search was conducted, supplemented by a manual search, and a search of public online information on paediatric antidepressant trials reviewed by regulatory agencies. Results: Data gathered from published and unpublished randomized controlled trials vary in their findings, with most of the studies showing a lack of efficacy characterized by a high placebo response rate. Conclusion: Differences from efficacy results with the same drugs in adult depression may be because of neurobiological developmental correlates, developmental differences in pharmacokinetics and pharmacodynamics, high rates of placebo response in children, and a number of methodological influences. There are several areas needing more attention in paediatric antidepressant clinical trials. Judicious use of published and unpublished studies to assess who may benefit from treatment with antidepressants seems warranted. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=23961537
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        Text: English
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      – SubjectFull: Teenagers
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              Text: Mar2007
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