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Efferent neurotransmitters in the human cochlea and vestibule.

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Title: Efferent neurotransmitters in the human cochlea and vestibule.
Authors: Schrott-Fischer, A. (AUTHOR), Kammen-Jolly, K. (AUTHOR), Scholtz, A. (AUTHOR), Rask-Andersen, H. (AUTHOR), Glueckert, >R. (AUTHOR), Eybalin, M. (AUTHOR)
Source: Acta Oto-Laryngologica. Jan2007, Vol. 127 Issue 1, p13-19. 7p. 1 Diagram.
Subjects: Neurotransmitters, Cochlea, Neural transmission, Inner ear, Acetylcholine, Enkephalins
Abstract: Conclusion: Current neurotransmission models based on animal studies on the mammalian inner ear not always reflect the situation in human. Rodents and primates show significant differences in characteristics of efferent innervation as well as the distribution of neuroactive substances. Objective: Immunohistochemistry demonstrates the mammalian efferent system as neurochemically complex and diverse: several neuroactive substances may co-exist within the same efferent terminal. Using light and electron microscopic immunohistochemistry, this study presents a comparative overview of the distribution patterns of choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, GABA, CGRP, and enkephalins within the peripheral nerve fiber systems of the human inner ear. Materials and methods: Human temporal bones were obtained post mortem and prepared according to a pre-embedding immunohistochemical technique to detect immunoreactivities to ChAT, GABA, CGRP, leu- and met-enkephalins at the electron microscopic level. Results: Immunoreactivities of all the antigens were present within both the lateral and medial efferent systems of the cochlea, whereas only ChAT, GABA, and CGRP were detected in efferent pathways of the vestibular end organs. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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  Data: Efferent neurotransmitters in the human cochlea and vestibule.
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  Data: <searchLink fieldCode="AR" term="%22Schrott-Fischer%2C+A%2E%22">Schrott-Fischer, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kammen-Jolly%2C+K%2E%22">Kammen-Jolly, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scholtz%2C+A%2E%22">Scholtz, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rask-Andersen%2C+H%2E%22">Rask-Andersen, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glueckert%2C+>R%2E%22">Glueckert, >R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eybalin%2C+M%2E%22">Eybalin, M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jan2007, Vol. 127 Issue 1, p13-19. 7p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Cochlea%22">Cochlea</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Inner+ear%22">Inner ear</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholine%22">Acetylcholine</searchLink><br /><searchLink fieldCode="DE" term="%22Enkephalins%22">Enkephalins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusion: Current neurotransmission models based on animal studies on the mammalian inner ear not always reflect the situation in human. Rodents and primates show significant differences in characteristics of efferent innervation as well as the distribution of neuroactive substances. Objective: Immunohistochemistry demonstrates the mammalian efferent system as neurochemically complex and diverse: several neuroactive substances may co-exist within the same efferent terminal. Using light and electron microscopic immunohistochemistry, this study presents a comparative overview of the distribution patterns of choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, GABA, CGRP, and enkephalins within the peripheral nerve fiber systems of the human inner ear. Materials and methods: Human temporal bones were obtained post mortem and prepared according to a pre-embedding immunohistochemical technique to detect immunoreactivities to ChAT, GABA, CGRP, leu- and met-enkephalins at the electron microscopic level. Results: Immunoreactivities of all the antigens were present within both the lateral and medial efferent systems of the cochlea, whereas only ChAT, GABA, and CGRP were detected in efferent pathways of the vestibular end organs. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00016480600652123
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        Text: English
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        Type: general
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      – SubjectFull: Neural transmission
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      – SubjectFull: Inner ear
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      – SubjectFull: Enkephalins
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              Text: Jan2007
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