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Lipids and essential fatty acids in patients presenting with self-harm.

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Title: Lipids and essential fatty acids in patients presenting with self-harm.
Authors: Garland, Malcolm R., Hallahan, Brian, McNamara, Mairead, Carney, Philip A., Grimes, Helen, Hibbeln, Joseph R., Harkin, Andrew, Conroy, Ronan M.
Source: British Journal of Psychiatry. Feb2007, Vol. 190, p112-117. 6p. 4 Charts.
Subjects: Cholesterol, Essential fatty acids, Preventive medicine, Serotoninergic mechanisms, Psychometrics
Abstract: Background: Low cholesterol has been reliably demonstrated in people who self-harm.Aims: To determine whether people who self-harm also have low levels of essential fatty acids (EFAs) and to examine associations between the EFAs and serotonergic function.Method: Depression, impulsivity and suicidal intent were measured in patients with self-harm (n=40) and matched controls, together with plasma lipids and EFAs. Platelet serotonergic studies were carried out in a subgroup (n=27).Results: Patients with self-harm had significantly more pathology on all psychometric measures, lower mean total cholesterol levels (4.18 (s.d.=0.93) v. 4.87 (s.d.=0.83) mmol/l, P=0.003) and lower mean total EFA levels (89. 5 (15.6) v.103.7 (17.1) microg/ml, P=0.0001) than controls after adjustment for confounding variables. Total n-3 and n-6 EFA levels were also significantly lower. Impulsivity and depression scores were significantly inversely correlated with both n-6 EFAs and n-3 EFAs, but were not associated with total or low-density lipoprotein cholesterol levels. Platelet serotonergic measures did not differ between groups, and were not related to psychobiological measures.Conclusions: Lower plasma EFA levels combined with low cholesterol concentrations were associated with self-harm as well as impulsivity and affect. This was not related to platelet serotonergic measures. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 24503304
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Lipids and essential fatty acids in patients presenting with self-harm.
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  Data: <searchLink fieldCode="AR" term="%22Garland%2C+Malcolm+R%2E%22">Garland, Malcolm R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hallahan%2C+Brian%22">Hallahan, Brian</searchLink><br /><searchLink fieldCode="AR" term="%22McNamara%2C+Mairead%22">McNamara, Mairead</searchLink><br /><searchLink fieldCode="AR" term="%22Carney%2C+Philip+A%2E%22">Carney, Philip A.</searchLink><br /><searchLink fieldCode="AR" term="%22Grimes%2C+Helen%22">Grimes, Helen</searchLink><br /><searchLink fieldCode="AR" term="%22Hibbeln%2C+Joseph+R%2E%22">Hibbeln, Joseph R.</searchLink><br /><searchLink fieldCode="AR" term="%22Harkin%2C+Andrew%22">Harkin, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Conroy%2C+Ronan+M%2E%22">Conroy, Ronan M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Feb2007, Vol. 190, p112-117. 6p. 4 Charts.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Cholesterol%22">Cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Essential+fatty+acids%22">Essential fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22Preventive+medicine%22">Preventive medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Psychometrics%22">Psychometrics</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>Low cholesterol has been reliably demonstrated in people who self-harm.<bold>Aims: </bold>To determine whether people who self-harm also have low levels of essential fatty acids (EFAs) and to examine associations between the EFAs and serotonergic function.<bold>Method: </bold>Depression, impulsivity and suicidal intent were measured in patients with self-harm (n=40) and matched controls, together with plasma lipids and EFAs. Platelet serotonergic studies were carried out in a subgroup (n=27).<bold>Results: </bold>Patients with self-harm had significantly more pathology on all psychometric measures, lower mean total cholesterol levels (4.18 (s.d.=0.93) v. 4.87 (s.d.=0.83) mmol/l, P=0.003) and lower mean total EFA levels (89. 5 (15.6) v.103.7 (17.1) microg/ml, P=0.0001) than controls after adjustment for confounding variables. Total n-3 and n-6 EFA levels were also significantly lower. Impulsivity and depression scores were significantly inversely correlated with both n-6 EFAs and n-3 EFAs, but were not associated with total or low-density lipoprotein cholesterol levels. Platelet serotonergic measures did not differ between groups, and were not related to psychobiological measures.<bold>Conclusions: </bold>Lower plasma EFA levels combined with low cholesterol concentrations were associated with self-harm as well as impulsivity and affect. This was not related to platelet serotonergic measures. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1192/bjp.bp.105.019562
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      – Code: eng
        Text: English
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      – SubjectFull: Cholesterol
        Type: general
      – SubjectFull: Essential fatty acids
        Type: general
      – SubjectFull: Preventive medicine
        Type: general
      – SubjectFull: Serotoninergic mechanisms
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      – SubjectFull: Psychometrics
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      – TitleFull: Lipids and essential fatty acids in patients presenting with self-harm.
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              Text: Feb2007
              Type: published
              Y: 2007
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              Value: 190
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