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Cardiac effects of different tricyclic antidepressant drugs.

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Title: Cardiac effects of different tricyclic antidepressant drugs.
Authors: Burrows, G. D., Vohra, J., Hunt, D., Sloman, J. G., Scoggins, B. A., Davies, Brian, Davies, B (AUTHOR)
Source: British Journal of Psychiatry. Oct76, Vol. 129, p335-341. 7p. 4 Diagrams, 2 Graphs.
Subjects: Antidepressants, Pharmacodynamics, Heart diseases, Heart conduction system, Heart beat, Depressed persons
Abstract: The effects of tricyclic antidepressants on the heart are reviewed. Statistically significant increases in heart rate and in atrioventricular conduction times were found following the administration of tricyclic drugs to 32 depressed patients. The method of His bundle electrocardiography was used to study atrioventricular conduction in ambulant patients and in patients admitted after an overdose of tricyclic antidepressant drugs. Distal conduction defects were frequently found in patients following tricyclic overdosage, but these were not seen with doxepin overdosage. Impaired distal conduction was also found in occasional patients on therapeutic doses of tricyclic drugs. Some animal experiments giving similar results to the above clinical findings are also described. The clinical implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Cardiac effects of different tricyclic antidepressant drugs.
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  Data: <searchLink fieldCode="AR" term="%22Burrows%2C+G%2E+D%2E%22">Burrows, G. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Vohra%2C+J%2E%22">Vohra, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hunt%2C+D%2E%22">Hunt, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Sloman%2C+J%2E+G%2E%22">Sloman, J. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Scoggins%2C+B%2E+A%2E%22">Scoggins, B. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+Brian%22">Davies, Brian</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+B%22">Davies, B</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Oct76, Vol. 129, p335-341. 7p. 4 Diagrams, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+diseases%22">Heart diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+conduction+system%22">Heart conduction system</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Depressed+persons%22">Depressed persons</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The effects of tricyclic antidepressants on the heart are reviewed. Statistically significant increases in heart rate and in atrioventricular conduction times were found following the administration of tricyclic drugs to 32 depressed patients. The method of His bundle electrocardiography was used to study atrioventricular conduction in ambulant patients and in patients admitted after an overdose of tricyclic antidepressant drugs. Distal conduction defects were frequently found in patients following tricyclic overdosage, but these were not seen with doxepin overdosage. Impaired distal conduction was also found in occasional patients on therapeutic doses of tricyclic drugs. Some animal experiments giving similar results to the above clinical findings are also described. The clinical implications of these findings are discussed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=24779733
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1192/bjp.129.4.335
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 335
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      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
      – SubjectFull: Heart diseases
        Type: general
      – SubjectFull: Heart conduction system
        Type: general
      – SubjectFull: Heart beat
        Type: general
      – SubjectFull: Depressed persons
        Type: general
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      – TitleFull: Cardiac effects of different tricyclic antidepressant drugs.
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            NameFull: Vohra, J.
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            NameFull: Hunt, D.
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            NameFull: Sloman, J. G.
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            NameFull: Scoggins, B. A.
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            NameFull: Davies, Brian
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              M: 10
              Text: Oct76
              Type: published
              Y: 1976
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              Value: 129
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