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Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.

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Title: Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.
Authors: Meaney, A. M., Smith, S., Howes, O. D., O'Brien, M., Murray, R. M., O'Keane, V.
Source: British Journal of Psychiatry. Jun2004, Vol. 184, p503-508. 6p. 1 Chart, 1 Graph.
Subjects: Antipsychotic agents, Psychiatric drugs, Schizophrenia, Psychoses, Pathological psychology, People with schizophrenia, Osteoporosis, Bone diseases, Bone density
Abstract: Background: High rates of osteoporosis in schizophrenia may result from the prolactin-raising effects of some antipsychotic medication. Aims To examine bone mineral density in relation to relevant endocrine variables in patients with schizophrenia taking prolactin-raising antipsychotics.Method: Fifty-five patients who had been receiving prolactin-raising antipsychotic medication for >10 years underwent dual-energy X-ray absorptiometry of their lumbar and hip bones. Among the endocrine variables assessed were plasma prolactin and sex hormones.Results: Age-related reduced bone mineral density measures were found in 17 (57%) of the male and 8 (32%) of the female patients. Higher doses of the female patients. Higher doses of medication were associated with increased rates of both hyperprolactinaemia and bone mineral density loss. Bone loss for the whole group was correlated with medication dose, and for men was inversely correlated with testosterone values.Conclusions: These results suggest that patients with schizophrenia on long-term prolactin-raising antipsychotic medication are at high risk of developing reduced bone mineral density as a consequence of hyperprolactinaemia-induced hypogonadism. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Meaney%2C+A%2E+M%2E%22">Meaney, A. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+S%2E%22">Smith, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes%2C+O%2E+D%2E%22">Howes, O. D.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Brien%2C+M%2E%22">O'Brien, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Murray%2C+R%2E+M%2E%22">Murray, R. M.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Keane%2C+V%2E%22">O'Keane, V.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jun2004, Vol. 184, p503-508. 6p. 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoporosis%22">Osteoporosis</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+diseases%22">Bone diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+density%22">Bone density</searchLink>
– Name: Abstract
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  Data: <bold>Background: </bold>High rates of osteoporosis in schizophrenia may result from the prolactin-raising effects of some antipsychotic medication. Aims To examine bone mineral density in relation to relevant endocrine variables in patients with schizophrenia taking prolactin-raising antipsychotics.<bold>Method: </bold>Fifty-five patients who had been receiving prolactin-raising antipsychotic medication for >10 years underwent dual-energy X-ray absorptiometry of their lumbar and hip bones. Among the endocrine variables assessed were plasma prolactin and sex hormones.<bold>Results: </bold>Age-related reduced bone mineral density measures were found in 17 (57%) of the male and 8 (32%) of the female patients. Higher doses of the female patients. Higher doses of medication were associated with increased rates of both hyperprolactinaemia and bone mineral density loss. Bone loss for the whole group was correlated with medication dose, and for men was inversely correlated with testosterone values.<bold>Conclusions: </bold>These results suggest that patients with schizophrenia on long-term prolactin-raising antipsychotic medication are at high risk of developing reduced bone mineral density as a consequence of hyperprolactinaemia-induced hypogonadism. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1192/bjp.184.6.503
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 503
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      – SubjectFull: Antipsychotic agents
        Type: general
      – SubjectFull: Psychiatric drugs
        Type: general
      – SubjectFull: Schizophrenia
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      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
      – SubjectFull: People with schizophrenia
        Type: general
      – SubjectFull: Osteoporosis
        Type: general
      – SubjectFull: Bone diseases
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      – SubjectFull: Bone density
        Type: general
    Titles:
      – TitleFull: Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.
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              Text: Jun2004
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              Y: 2004
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              Value: 184
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