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Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene.

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Title: Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene.
Authors: Maziade, Michel, Martinez, Maria, Rodrigue, Caroline, Gauthier, Benoît, Tremblay, Guy, Fournier, Christian, Bissonnette, Luc, Simard, Carl, Roy, Marc-André, Rouillard, Eric, Mérette, Chantal, Maziade, M (AUTHOR), Martinez, M (AUTHOR), Rodrigue, C (AUTHOR), Gauthier, B (AUTHOR), Tremblay, G (AUTHOR), Fournier, C (AUTHOR), Bissonnette, L (AUTHOR), Simard, C (AUTHOR), Roy, M A (AUTHOR)
Source: British Journal of Psychiatry. Jan97, Vol. 170, p27-30. 4p. 2 Charts.
Subjects: Schizophrenia, Psychoses, Dopamine receptors, People with schizophrenia, Pathological psychology, Genes, Age factors in disease, Alleles, Cell receptors, Comparative studies, Research methodology, Medical cooperation, Research, Evaluation research, Genotypes
Abstract: Background: The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. We tested for an allelic association between schizophrenia and the DRD3 Mscl alleles, hypothesising heterogeneity between childhood/early adolescence-onset schizophrenia (CO-SZ) and adult-onset schizophrenia (A-SZ).Method: The frequencies of the DRD3 alleles were compared between 70 DSM-III-R schizophrenics (35 CO-SZ and 35 A-SZ) and 79 controls.Results: Compared with the controls, the subsample of A-SZ, but not CO-SZ, showed an over-proportion (P = 0.025) of allele 1. The association was not found in the total sample, combining the two subsamples.Conclusions: Consistently with former studies, our data suggest an aetiological heterogeneity between CO-SZ and A-SZ and a possible specificity of the excess of allele 1 to the familial form of schizophrenia and to schizophrenia with a better outcome. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 25068335
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  Data: Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene.
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  Data: <searchLink fieldCode="AR" term="%22Maziade%2C+Michel%22">Maziade, Michel</searchLink><br /><searchLink fieldCode="AR" term="%22Martinez%2C+Maria%22">Martinez, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Rodrigue%2C+Caroline%22">Rodrigue, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Gauthier%2C+Benoît%22">Gauthier, Benoît</searchLink><br /><searchLink fieldCode="AR" term="%22Tremblay%2C+Guy%22">Tremblay, Guy</searchLink><br /><searchLink fieldCode="AR" term="%22Fournier%2C+Christian%22">Fournier, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Bissonnette%2C+Luc%22">Bissonnette, Luc</searchLink><br /><searchLink fieldCode="AR" term="%22Simard%2C+Carl%22">Simard, Carl</searchLink><br /><searchLink fieldCode="AR" term="%22Roy%2C+Marc-André%22">Roy, Marc-André</searchLink><br /><searchLink fieldCode="AR" term="%22Rouillard%2C+Eric%22">Rouillard, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22Mérette%2C+Chantal%22">Mérette, Chantal</searchLink><br /><searchLink fieldCode="AR" term="%22Maziade%2C+M%22">Maziade, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martinez%2C+M%22">Martinez, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigue%2C+C%22">Rodrigue, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gauthier%2C+B%22">Gauthier, B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tremblay%2C+G%22">Tremblay, G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fournier%2C+C%22">Fournier, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bissonnette%2C+L%22">Bissonnette, L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simard%2C+C%22">Simard, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roy%2C+M+A%22">Roy, M A</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jan97, Vol. 170, p27-30. 4p. 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Age+factors+in+disease%22">Age factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Alleles%22">Alleles</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+receptors%22">Cell receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. We tested for an allelic association between schizophrenia and the DRD3 Mscl alleles, hypothesising heterogeneity between childhood/early adolescence-onset schizophrenia (CO-SZ) and adult-onset schizophrenia (A-SZ).<bold>Method: </bold>The frequencies of the DRD3 alleles were compared between 70 DSM-III-R schizophrenics (35 CO-SZ and 35 A-SZ) and 79 controls.<bold>Results: </bold>Compared with the controls, the subsample of A-SZ, but not CO-SZ, showed an over-proportion (P = 0.025) of allele 1. The association was not found in the total sample, combining the two subsamples.<bold>Conclusions: </bold>Consistently with former studies, our data suggest an aetiological heterogeneity between CO-SZ and A-SZ and a possible specificity of the excess of allele 1 to the familial form of schizophrenia and to schizophrenia with a better outcome. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1192/bjp.170.1.27
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      – Code: eng
        Text: English
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        StartPage: 27
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      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Psychoses
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      – SubjectFull: Dopamine receptors
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      – SubjectFull: People with schizophrenia
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      – SubjectFull: Genes
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      – SubjectFull: Age factors in disease
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      – SubjectFull: Cell receptors
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              Text: Jan97
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