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Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users.

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Title: Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users.
Authors: Semple, David M., Ebmeier, Klaus P., Glabus, Micahel F., O'Carroll, Ronan E., Johnstone, Eve C., Semple, D M (AUTHOR), Ebmeier, K P (AUTHOR), Glabus, M F (AUTHOR), O'Carroll, R E (AUTHOR), Johnstone, E C (AUTHOR)
Source: British Journal of Psychiatry. Jul99, Vol. 175, p63-69. 7p. 2 Charts, 3 Graphs.
Subjects: Ecstasy (Drug), Hallucinogenic drugs, Substance use of young adults, Serotonin, Psychiatry, Cerebral cortex
Abstract: Background: The use of MDMA ('ecstasy') is common among young people in Western countries. Animal models of MDMA toxicity suggest a loss of serotonergic neurons, and potentially implicate in the development of significant psychiatric morbidity in humans.Aims: To test whether long-term use of MDMA can produce abnormalities in cerebral serotonin, but not dopamine, transporter binding measured by single photon emission computed tomography (SPECT).Method: Ten male regular ecstasy users and 10 well-matched controls recruited from the same community sources participated in SPECT with the serotonin transporter (SERT) ligand [123I] beta-CIT. Dopamine transporter binding was determined from scans acquired 23 hours after injection of the tracer.Results: Ecstasy users showed a cortical reduction of SERT binding, particularly prominent in primary sensory-motor cortex, with normal dopamine transporter binding in lenticular nuclei.Conclusions: This cross-sectional association study provides suggestive evidence for specific, at least temporary, serotonergic neurotoxicity of MDMA in humans. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 25163984
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
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  Data: Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Semple%2C+David+M%2E%22">Semple, David M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ebmeier%2C+Klaus+P%2E%22">Ebmeier, Klaus P.</searchLink><br /><searchLink fieldCode="AR" term="%22Glabus%2C+Micahel+F%2E%22">Glabus, Micahel F.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Carroll%2C+Ronan+E%2E%22">O'Carroll, Ronan E.</searchLink><br /><searchLink fieldCode="AR" term="%22Johnstone%2C+Eve+C%2E%22">Johnstone, Eve C.</searchLink><br /><searchLink fieldCode="AR" term="%22Semple%2C+D+M%22">Semple, D M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ebmeier%2C+K+P%22">Ebmeier, K P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glabus%2C+M+F%22">Glabus, M F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22O'Carroll%2C+R+E%22">O'Carroll, R E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnstone%2C+E+C%22">Johnstone, E C</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jul99, Vol. 175, p63-69. 7p. 2 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Ecstasy+%28Drug%29%22">Ecstasy (Drug)</searchLink><br /><searchLink fieldCode="DE" term="%22Hallucinogenic+drugs%22">Hallucinogenic drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+use+of+young+adults%22">Substance use of young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatry%22">Psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortex%22">Cerebral cortex</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>The use of MDMA ('ecstasy') is common among young people in Western countries. Animal models of MDMA toxicity suggest a loss of serotonergic neurons, and potentially implicate in the development of significant psychiatric morbidity in humans.<bold>Aims: </bold>To test whether long-term use of MDMA can produce abnormalities in cerebral serotonin, but not dopamine, transporter binding measured by single photon emission computed tomography (SPECT).<bold>Method: </bold>Ten male regular ecstasy users and 10 well-matched controls recruited from the same community sources participated in SPECT with the serotonin transporter (SERT) ligand [123I] beta-CIT. Dopamine transporter binding was determined from scans acquired 23 hours after injection of the tracer.<bold>Results: </bold>Ecstasy users showed a cortical reduction of SERT binding, particularly prominent in primary sensory-motor cortex, with normal dopamine transporter binding in lenticular nuclei.<bold>Conclusions: </bold>This cross-sectional association study provides suggestive evidence for specific, at least temporary, serotonergic neurotoxicity of MDMA in humans. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1192/bjp.175.1.63
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 63
    Subjects:
      – SubjectFull: Ecstasy (Drug)
        Type: general
      – SubjectFull: Hallucinogenic drugs
        Type: general
      – SubjectFull: Substance use of young adults
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      – SubjectFull: Serotonin
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      – SubjectFull: Psychiatry
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      – SubjectFull: Cerebral cortex
        Type: general
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      – TitleFull: Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users.
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            – D: 01
              M: 07
              Text: Jul99
              Type: published
              Y: 1999
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