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Tardive dyskinesia in schizophrenia. Relationship to minor physical anomalies, frontal lobe dysfunction and cerebral structure on magnetic resonance imaging.

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Title: Tardive dyskinesia in schizophrenia. Relationship to minor physical anomalies, frontal lobe dysfunction and cerebral structure on magnetic resonance imaging.
Authors: Waddington, John L., O'Callaghan, Eadbhard, Buckley, Peter, Madigan, Cathy, Redmond, Oonagh, Stack, John P., Kinsella, Anthony, Larkin, Conall, Ennis, Joseph T., Waddington, J L (AUTHOR), O'Callaghan, E (AUTHOR), Buckley, P (AUTHOR), Madigan, C (AUTHOR), Redmond, O (AUTHOR), Stack, J P (AUTHOR), Kinsella, A (AUTHOR), Larkin, C (AUTHOR), Ennis, J T (AUTHOR)
Source: British Journal of Psychiatry. Jul95, Vol. 167, p41-44. 4p.
Subjects: Schizophrenia, Tardive dyskinesia, Psychoses, Magnetic resonance imaging, Frontal lobe, Cerebral ventricles
Abstract: Background: It was hypothesised that schizophrenic patients with tardive dyskinesia show an excess of neurodevelopmental disturbance, particularly minor physical anomalies, in association with cognitive dysfunction and abnormalities of cerebral structure.Method: Forty-seven out-patients with a DSM-III diagnosis of schizophrenia were examined for tardive dyskinesia using the Abnormal Involuntary Movement Scale; they were examined also for minor physical anomalies and neuropsychological test performance. Cortical atrophy, signal hyperintensities and lateral ventricular volume were determined on magnetic resonance imaging.Results: Patients with and without tardive dyskinesia could not be distinguished by age, gender distribution or a number of clinical measures; however, patients with tardive dyskinesia sorted fewer categories on the Wisconsin Card Sorting Test (P = 0.04). Cerebral structure in patients with and without tardive dyskinesia could not be distinguished on magnetic resonance imaging but those with dyskinesia, all of whom showed involvement of the orofacial region, showed more evident minor physical anomalies of the head relative to those of the periphery (P = 0.02).Conclusions: Tardive orofacial dyskinesia in schizophrenia appears to be associated particularly with poorer frontal lobe function, while predominance of craniofacial dysmorphogenesis may constitute a vulnerability factor that is related to the early origins of the disease process. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Tardive dyskinesia in schizophrenia. Relationship to minor physical anomalies, frontal lobe dysfunction and cerebral structure on magnetic resonance imaging.
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  Data: <searchLink fieldCode="AR" term="%22Waddington%2C+John+L%2E%22">Waddington, John L.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Callaghan%2C+Eadbhard%22">O'Callaghan, Eadbhard</searchLink><br /><searchLink fieldCode="AR" term="%22Buckley%2C+Peter%22">Buckley, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Madigan%2C+Cathy%22">Madigan, Cathy</searchLink><br /><searchLink fieldCode="AR" term="%22Redmond%2C+Oonagh%22">Redmond, Oonagh</searchLink><br /><searchLink fieldCode="AR" term="%22Stack%2C+John+P%2E%22">Stack, John P.</searchLink><br /><searchLink fieldCode="AR" term="%22Kinsella%2C+Anthony%22">Kinsella, Anthony</searchLink><br /><searchLink fieldCode="AR" term="%22Larkin%2C+Conall%22">Larkin, Conall</searchLink><br /><searchLink fieldCode="AR" term="%22Ennis%2C+Joseph+T%2E%22">Ennis, Joseph T.</searchLink><br /><searchLink fieldCode="AR" term="%22Waddington%2C+J+L%22">Waddington, J L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22O'Callaghan%2C+E%22">O'Callaghan, E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buckley%2C+P%22">Buckley, P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Madigan%2C+C%22">Madigan, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Redmond%2C+O%22">Redmond, O</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stack%2C+J+P%22">Stack, J P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kinsella%2C+A%22">Kinsella, A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Larkin%2C+C%22">Larkin, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ennis%2C+J+T%22">Ennis, J T</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jul95, Vol. 167, p41-44. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Tardive+dyskinesia%22">Tardive dyskinesia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ventricles%22">Cerebral ventricles</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>It was hypothesised that schizophrenic patients with tardive dyskinesia show an excess of neurodevelopmental disturbance, particularly minor physical anomalies, in association with cognitive dysfunction and abnormalities of cerebral structure.<bold>Method: </bold>Forty-seven out-patients with a DSM-III diagnosis of schizophrenia were examined for tardive dyskinesia using the Abnormal Involuntary Movement Scale; they were examined also for minor physical anomalies and neuropsychological test performance. Cortical atrophy, signal hyperintensities and lateral ventricular volume were determined on magnetic resonance imaging.<bold>Results: </bold>Patients with and without tardive dyskinesia could not be distinguished by age, gender distribution or a number of clinical measures; however, patients with tardive dyskinesia sorted fewer categories on the Wisconsin Card Sorting Test (P = 0.04). Cerebral structure in patients with and without tardive dyskinesia could not be distinguished on magnetic resonance imaging but those with dyskinesia, all of whom showed involvement of the orofacial region, showed more evident minor physical anomalies of the head relative to those of the periphery (P = 0.02).<bold>Conclusions: </bold>Tardive orofacial dyskinesia in schizophrenia appears to be associated particularly with poorer frontal lobe function, while predominance of craniofacial dysmorphogenesis may constitute a vulnerability factor that is related to the early origins of the disease process. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1192/bjp.167.1.41
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        Text: English
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