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Crossed cortico-spinal motor control after capsular stroke.

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Title: Crossed cortico-spinal motor control after capsular stroke.
Authors: Braun, Christoph (AUTHOR), Staudt, Martin (AUTHOR), Schmitt, Carmen (AUTHOR), Preissl, Hubert (AUTHOR), Birbaumer, Niels (AUTHOR), Gerloff, Christian (AUTHOR)
Source: European Journal of Neuroscience. May2007, Vol. 25 Issue 9, p2935-2945. 11p.
Subjects: Cerebrovascular disease, Motor cortex, Transcranial magnetic stimulation, Magnetoencephalography, Brain magnetic fields measurement, Frontal lobe
Abstract: While it is widely accepted that multiple nonprimary motor areas such as the dorsal premotor cortex contribute to recovery from stroke, the contribution of the ipsilesional and contralesional primary motor cortex (M1) is controversial. It has been suggested that re-instating ‘near normal’ activation patterns is a good strategy for recovery of function [Baron et al., (2004) Cerebrovasc. Dis., 18, 260–267; Ward & Cohen, (2004) Arch. Neurol., 61, 1844–1848]. The present study addressed this aspect of stroke recovery by combining transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) in a cross-sectional design on nine patients with well-recovered motor function 17.6 ± 5.5 months (mean ± SD) after subcortical stroke. While TMS was applied to probe the integrity of the cortico-spinal tract (CST) at rest, MEG was used to test for recruitment of CST pathways during a motor challenge [cortico-muscular coherence (CMC) in a precision grip task]. With both techniques, crossed cortico-spinal connectivity could be demonstrated. A significant correlation ( r = 0.85) of CMC magnitude and recovered muscle strength underlined the functional relevance of crossed CST integrity for successful recovery. In conclusion, at the descriptive level, crossed CST connectivity is a common finding in well-recovered patients with capsular stroke. This renders it likely that maintaining or regaining use of crossed CST fibers is one way to achieve effective recovery. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Crossed cortico-spinal motor control after capsular stroke.
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  Data: <searchLink fieldCode="AR" term="%22Braun%2C+Christoph%22">Braun, Christoph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Staudt%2C+Martin%22">Staudt, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmitt%2C+Carmen%22">Schmitt, Carmen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Preissl%2C+Hubert%22">Preissl, Hubert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birbaumer%2C+Niels%22">Birbaumer, Niels</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerloff%2C+Christian%22">Gerloff, Christian</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2007, Vol. 25 Issue 9, p2935-2945. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Cerebrovascular+disease%22">Cerebrovascular disease</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+cortex%22">Motor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+magnetic+stimulation%22">Transcranial magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetoencephalography%22">Magnetoencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+magnetic+fields+measurement%22">Brain magnetic fields measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: While it is widely accepted that multiple nonprimary motor areas such as the dorsal premotor cortex contribute to recovery from stroke, the contribution of the ipsilesional and contralesional primary motor cortex (M1) is controversial. It has been suggested that re-instating ‘near normal’ activation patterns is a good strategy for recovery of function [Baron et al., (2004) Cerebrovasc. Dis., 18, 260–267; Ward & Cohen, (2004) Arch. Neurol., 61, 1844–1848]. The present study addressed this aspect of stroke recovery by combining transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) in a cross-sectional design on nine patients with well-recovered motor function 17.6 ± 5.5 months (mean ± SD) after subcortical stroke. While TMS was applied to probe the integrity of the cortico-spinal tract (CST) at rest, MEG was used to test for recruitment of CST pathways during a motor challenge [cortico-muscular coherence (CMC) in a precision grip task]. With both techniques, crossed cortico-spinal connectivity could be demonstrated. A significant correlation ( r = 0.85) of CMC magnitude and recovered muscle strength underlined the functional relevance of crossed CST integrity for successful recovery. In conclusion, at the descriptive level, crossed CST connectivity is a common finding in well-recovered patients with capsular stroke. This renders it likely that maintaining or regaining use of crossed CST fibers is one way to achieve effective recovery. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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