Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: A comparison of quantitative MRI and neuropsychological findings.
Saved in:
| Title: | Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: A comparison of quantitative MRI and neuropsychological findings. |
|---|---|
| Authors: | Fearing, MichaelA. (AUTHOR), Bigler, ErinD. (AUTHOR), Norton, Maria (AUTHOR), Tschanz, Jo Ann (AUTHOR), Hulette, Christine (AUTHOR), Leslie, Carol (AUTHOR), Welsh-Bohmer, Kathleen (AUTHOR), the Cache County Investigators (AUTHOR) |
| Source: | Journal of Clinical & Experimental Neuropsychology. Jul2007, Vol. 29 Issue 5, p553-560. 8p. 3 Charts. |
| Subjects: | Alzheimer's patients, Neuropsychological tests, Autopsy, Alzheimer's disease diagnosis, Magnetic resonance imaging, Diagnostic imaging |
| Abstract: | Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Clinical & Experimental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 25382044 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: A comparison of quantitative MRI and neuropsychological findings. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fearing%2C+MichaelA%2E%22">Fearing, MichaelA.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bigler%2C+ErinD%2E%22">Bigler, ErinD.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Norton%2C+Maria%22">Norton, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tschanz%2C+Jo+Ann%22">Tschanz, Jo Ann</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hulette%2C+Christine%22">Hulette, Christine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leslie%2C+Carol%22">Leslie, Carol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Welsh-Bohmer%2C+Kathleen%22">Welsh-Bohmer, Kathleen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22the+Cache+County+Investigators%22">the Cache County Investigators</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+%26+Experimental+Neuropsychology%22">Journal of Clinical & Experimental Neuropsychology</searchLink>. Jul2007, Vol. 29 Issue 5, p553-560. 8p. 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Autopsy%22">Autopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease+diagnosis%22">Alzheimer's disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Clinical & Experimental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=25382044 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/13803390600826579 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 553 Subjects: – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Neuropsychological tests Type: general – SubjectFull: Autopsy Type: general – SubjectFull: Alzheimer's disease diagnosis Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Diagnostic imaging Type: general Titles: – TitleFull: Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: A comparison of quantitative MRI and neuropsychological findings. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fearing, MichaelA. – PersonEntity: Name: NameFull: Bigler, ErinD. – PersonEntity: Name: NameFull: Norton, Maria – PersonEntity: Name: NameFull: Tschanz, Jo Ann – PersonEntity: Name: NameFull: Hulette, Christine – PersonEntity: Name: NameFull: Leslie, Carol – PersonEntity: Name: NameFull: Welsh-Bohmer, Kathleen – PersonEntity: Name: NameFull: the Cache County Investigators IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 13803395 Numbering: – Type: volume Value: 29 – Type: issue Value: 5 Titles: – TitleFull: Journal of Clinical & Experimental Neuropsychology Type: main |
| ResultId | 1 |
