Bibliographic Details
| Title: |
TRP channels in mechanosensation: direct or indirect activation? |
| Authors: |
Christensen, Adam P., Corey, David P. |
| Source: |
Nature Reviews Neuroscience. Jul2007, Vol. 8 Issue 7, p510-521. 12p. 6 Diagrams, 2 Charts, 1 Graph. |
| Subjects: |
TRP channels, Ion channels, Neural receptors, Sensory receptors, Nematodes |
| Abstract: |
Ion channels of the transient receptor potential (TRP) superfamily are involved in a wide variety of neural signalling processes, most prominently in sensory receptor cells. They are essential for mechanosensation in systems ranging from fruitfly hearing, to nematode touch, to mouse mechanical pain. However, it is unclear in many instances whether a TRP channel directly transduces the mechanical stimulus or is part of a downstream signalling pathway. Here, we propose criteria for establishing direct mechanical activation of ion channels and review these criteria in a number of mechanosensory systems in which TRP channels are involved. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
