View in EDS PDF Full Text

TRP channels in mechanosensation: direct or indirect activation?

Saved in:
Bibliographic Details
Title: TRP channels in mechanosensation: direct or indirect activation?
Authors: Christensen, Adam P., Corey, David P.
Source: Nature Reviews Neuroscience. Jul2007, Vol. 8 Issue 7, p510-521. 12p. 6 Diagrams, 2 Charts, 1 Graph.
Subjects: TRP channels, Ion channels, Neural receptors, Sensory receptors, Nematodes
Abstract: Ion channels of the transient receptor potential (TRP) superfamily are involved in a wide variety of neural signalling processes, most prominently in sensory receptor cells. They are essential for mechanosensation in systems ranging from fruitfly hearing, to nematode touch, to mouse mechanical pain. However, it is unclear in many instances whether a TRP channel directly transduces the mechanical stimulus or is part of a downstream signalling pathway. Here, we propose criteria for establishing direct mechanical activation of ion channels and review these criteria in a number of mechanosensory systems in which TRP channels are involved. [ABSTRACT FROM AUTHOR]
Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 25463757
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: TRP channels in mechanosensation: direct or indirect activation?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Christensen%2C+Adam+P%2E%22">Christensen, Adam P.</searchLink><br /><searchLink fieldCode="AR" term="%22Corey%2C+David+P%2E%22">Corey, David P.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature+Reviews+Neuroscience%22">Nature Reviews Neuroscience</searchLink>. Jul2007, Vol. 8 Issue 7, p510-521. 12p. 6 Diagrams, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22TRP+channels%22">TRP channels</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+channels%22">Ion channels</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+receptors%22">Neural receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+receptors%22">Sensory receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Nematodes%22">Nematodes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Ion channels of the transient receptor potential (TRP) superfamily are involved in a wide variety of neural signalling processes, most prominently in sensory receptor cells. They are essential for mechanosensation in systems ranging from fruitfly hearing, to nematode touch, to mouse mechanical pain. However, it is unclear in many instances whether a TRP channel directly transduces the mechanical stimulus or is part of a downstream signalling pathway. Here, we propose criteria for establishing direct mechanical activation of ion channels and review these criteria in a number of mechanosensory systems in which TRP channels are involved. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=25463757
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nrn2149
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 510
    Subjects:
      – SubjectFull: TRP channels
        Type: general
      – SubjectFull: Ion channels
        Type: general
      – SubjectFull: Neural receptors
        Type: general
      – SubjectFull: Sensory receptors
        Type: general
      – SubjectFull: Nematodes
        Type: general
    Titles:
      – TitleFull: TRP channels in mechanosensation: direct or indirect activation?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Christensen, Adam P.
      – PersonEntity:
          Name:
            NameFull: Corey, David P.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2007
              Type: published
              Y: 2007
          Identifiers:
            – Type: issn-print
              Value: 1471003X
          Numbering:
            – Type: volume
              Value: 8
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Nature Reviews Neuroscience
              Type: main
ResultId 1