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The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization.

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Title: The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization.
Authors: Cuomo, Christina A., Güldener, Ulrich, Jin-Rong Xu, Trail, Frances, Turgeon, B. Gillian, Di Pietro, Antonio, Walton, Jonathan D., Li-Jun Ma, Baker, Scott E., Rep, Martijn, Adam, Gerhard, Antoniw, John, Baldwin, Thomas, Calvo, Sarah, Yueh-Long Chang, DeCaprio, David, Gale, Liane R., Gnerre, Sante, Goswami, Rubella S., Hammond-Kosack, Kim
Source: Science (pre-March 2025). 9/7/2007, Vol. 317 Issue 5843, p1400-1402. 3p.
Subjects: Fusarium, Grasses, Genomes, Pathogenic microorganisms, Grain, Genes, Telomeres, Plants
Abstract: We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Cuomo%2C+Christina+A%2E%22">Cuomo, Christina A.</searchLink><br /><searchLink fieldCode="AR" term="%22Güldener%2C+Ulrich%22">Güldener, Ulrich</searchLink><br /><searchLink fieldCode="AR" term="%22Jin-Rong+Xu%22">Jin-Rong Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Trail%2C+Frances%22">Trail, Frances</searchLink><br /><searchLink fieldCode="AR" term="%22Turgeon%2C+B%2E+Gillian%22">Turgeon, B. Gillian</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Pietro%2C+Antonio%22">Di Pietro, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Walton%2C+Jonathan+D%2E%22">Walton, Jonathan D.</searchLink><br /><searchLink fieldCode="AR" term="%22Li-Jun+Ma%22">Li-Jun Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Baker%2C+Scott+E%2E%22">Baker, Scott E.</searchLink><br /><searchLink fieldCode="AR" term="%22Rep%2C+Martijn%22">Rep, Martijn</searchLink><br /><searchLink fieldCode="AR" term="%22Adam%2C+Gerhard%22">Adam, Gerhard</searchLink><br /><searchLink fieldCode="AR" term="%22Antoniw%2C+John%22">Antoniw, John</searchLink><br /><searchLink fieldCode="AR" term="%22Baldwin%2C+Thomas%22">Baldwin, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Calvo%2C+Sarah%22">Calvo, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Yueh-Long+Chang%22">Yueh-Long Chang</searchLink><br /><searchLink fieldCode="AR" term="%22DeCaprio%2C+David%22">DeCaprio, David</searchLink><br /><searchLink fieldCode="AR" term="%22Gale%2C+Liane+R%2E%22">Gale, Liane R.</searchLink><br /><searchLink fieldCode="AR" term="%22Gnerre%2C+Sante%22">Gnerre, Sante</searchLink><br /><searchLink fieldCode="AR" term="%22Goswami%2C+Rubella+S%2E%22">Goswami, Rubella S.</searchLink><br /><searchLink fieldCode="AR" term="%22Hammond-Kosack%2C+Kim%22">Hammond-Kosack, Kim</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/7/2007, Vol. 317 Issue 5843, p1400-1402. 3p.
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  Data: We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=26652179
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        Value: 10.1126/science.1143708
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        Text: English
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        PageCount: 3
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      – SubjectFull: Fusarium
        Type: general
      – SubjectFull: Grasses
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      – SubjectFull: Genomes
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      – SubjectFull: Pathogenic microorganisms
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      – SubjectFull: Plants
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