COGNITIVE EFFECTS OF SHORT-TERM USE OF RALOXIFENE: A RANDOMIZED CLINICAL TRIAL.
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| Title: | COGNITIVE EFFECTS OF SHORT-TERM USE OF RALOXIFENE: A RANDOMIZED CLINICAL TRIAL. |
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| Authors: | BUCKWALTER, J. G. (AUTHOR), GEIGER, A. M. (AUTHOR), PARSONS, T. D. (AUTHOR), HANDLER, J. (AUTHOR), HOWES, J. (AUTHOR), LEHMER, R. R. (AUTHOR) |
| Source: | International Journal of Neuroscience. Nov2007, Vol. 117 Issue 11, p1579-1590. 12p. 2 Charts. |
| Subjects: | Medical experimentation on humans, Medical research, Estrogen antagonists, Sex hormones, Steroid hormones, Clinical medicine |
| Abstract: | Two questions regarding findings from the Women's Health Initiative are (1) What is the effect of various hormonal regimens including selective estrogen receptor modulators? and (2) Is the negative effect on cognitive functioning related to the older age (65+ years) of the women? This study addresses these two questions in a short-term randomized trial of the effects of raloxifene versus alendronate on cognition. The study found only one significant interaction where the raloxifene and alendronate group changed differently across the two testing occasions. Hence, raloxifene does not have any impact, positive or negative, on short-term cognitive functioning when compared to alendronate. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Two questions regarding findings from the Women's Health Initiative are (1) What is the effect of various hormonal regimens including selective estrogen receptor modulators? and (2) Is the negative effect on cognitive functioning related to the older age (65+ years) of the women? This study addresses these two questions in a short-term randomized trial of the effects of raloxifene versus alendronate on cognition. The study found only one significant interaction where the raloxifene and alendronate group changed differently across the two testing occasions. Hence, raloxifene does not have any impact, positive or negative, on short-term cognitive functioning when compared to alendronate. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00207454 |
| DOI: | 10.1080/00207450701239392 |
