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COGNITIVE EFFECTS OF SHORT-TERM USE OF RALOXIFENE: A RANDOMIZED CLINICAL TRIAL.

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Title: COGNITIVE EFFECTS OF SHORT-TERM USE OF RALOXIFENE: A RANDOMIZED CLINICAL TRIAL.
Authors: BUCKWALTER, J. G. (AUTHOR), GEIGER, A. M. (AUTHOR), PARSONS, T. D. (AUTHOR), HANDLER, J. (AUTHOR), HOWES, J. (AUTHOR), LEHMER, R. R. (AUTHOR)
Source: International Journal of Neuroscience. Nov2007, Vol. 117 Issue 11, p1579-1590. 12p. 2 Charts.
Subjects: Medical experimentation on humans, Medical research, Estrogen antagonists, Sex hormones, Steroid hormones, Clinical medicine
Abstract: Two questions regarding findings from the Women's Health Initiative are (1) What is the effect of various hormonal regimens including selective estrogen receptor modulators? and (2) Is the negative effect on cognitive functioning related to the older age (65+ years) of the women? This study addresses these two questions in a short-term randomized trial of the effects of raloxifene versus alendronate on cognition. The study found only one significant interaction where the raloxifene and alendronate group changed differently across the two testing occasions. Hence, raloxifene does not have any impact, positive or negative, on short-term cognitive functioning when compared to alendronate. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: COGNITIVE EFFECTS OF SHORT-TERM USE OF RALOXIFENE: A RANDOMIZED CLINICAL TRIAL.
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  Data: <searchLink fieldCode="DE" term="%22Medical+experimentation+on+humans%22">Medical experimentation on humans</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen+antagonists%22">Estrogen antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+hormones%22">Sex hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Steroid+hormones%22">Steroid hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+medicine%22">Clinical medicine</searchLink>
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  Data: Two questions regarding findings from the Women's Health Initiative are (1) What is the effect of various hormonal regimens including selective estrogen receptor modulators? and (2) Is the negative effect on cognitive functioning related to the older age (65+ years) of the women? This study addresses these two questions in a short-term randomized trial of the effects of raloxifene versus alendronate on cognition. The study found only one significant interaction where the raloxifene and alendronate group changed differently across the two testing occasions. Hence, raloxifene does not have any impact, positive or negative, on short-term cognitive functioning when compared to alendronate. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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