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Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia.

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Title: Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia.
Authors: Morrison, Hilary G., McArthur, Andrew G., Gillin, Frances D., Aley, Stephen B., Adam, Rodney D., Olsen, Gary J., Best, Aaron A., Cande, W. Zacheus, Feng Chen, Cipriano, Michael J., Davids, Barbara J., Dawson, Scott C., Elmendorf, Heidi G., Hehl, Adrian B., Holder, Michael E., Huse, Susan M., Kim, Ulandt U., Lasek-Nesselquist, Erica, Manning, Gerard, Nigam, Anuranjini
Source: Science (pre-March 2025). 9/28/2007, Vol. 317 Issue 5846, p1921-1926. 6p. 2 Diagrams, 2 Charts.
Subjects: Giardia lamblia, Eukaryotic cells, Intestinal parasites, Introns, Mitochondrial pathology, DNA replication, Protein kinases, Archaebacteria, Heterozygosity
Abstract: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity, supporting recent speculations that this organism is sexual. This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia.
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  Data: <searchLink fieldCode="AR" term="%22Morrison%2C+Hilary+G%2E%22">Morrison, Hilary G.</searchLink><br /><searchLink fieldCode="AR" term="%22McArthur%2C+Andrew+G%2E%22">McArthur, Andrew G.</searchLink><br /><searchLink fieldCode="AR" term="%22Gillin%2C+Frances+D%2E%22">Gillin, Frances D.</searchLink><br /><searchLink fieldCode="AR" term="%22Aley%2C+Stephen+B%2E%22">Aley, Stephen B.</searchLink><br /><searchLink fieldCode="AR" term="%22Adam%2C+Rodney+D%2E%22">Adam, Rodney D.</searchLink><br /><searchLink fieldCode="AR" term="%22Olsen%2C+Gary+J%2E%22">Olsen, Gary J.</searchLink><br /><searchLink fieldCode="AR" term="%22Best%2C+Aaron+A%2E%22">Best, Aaron A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cande%2C+W%2E+Zacheus%22">Cande, W. Zacheus</searchLink><br /><searchLink fieldCode="AR" term="%22Feng+Chen%22">Feng Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Cipriano%2C+Michael+J%2E%22">Cipriano, Michael J.</searchLink><br /><searchLink fieldCode="AR" term="%22Davids%2C+Barbara+J%2E%22">Davids, Barbara J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dawson%2C+Scott+C%2E%22">Dawson, Scott C.</searchLink><br /><searchLink fieldCode="AR" term="%22Elmendorf%2C+Heidi+G%2E%22">Elmendorf, Heidi G.</searchLink><br /><searchLink fieldCode="AR" term="%22Hehl%2C+Adrian+B%2E%22">Hehl, Adrian B.</searchLink><br /><searchLink fieldCode="AR" term="%22Holder%2C+Michael+E%2E%22">Holder, Michael E.</searchLink><br /><searchLink fieldCode="AR" term="%22Huse%2C+Susan+M%2E%22">Huse, Susan M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Ulandt+U%2E%22">Kim, Ulandt U.</searchLink><br /><searchLink fieldCode="AR" term="%22Lasek-Nesselquist%2C+Erica%22">Lasek-Nesselquist, Erica</searchLink><br /><searchLink fieldCode="AR" term="%22Manning%2C+Gerard%22">Manning, Gerard</searchLink><br /><searchLink fieldCode="AR" term="%22Nigam%2C+Anuranjini%22">Nigam, Anuranjini</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/28/2007, Vol. 317 Issue 5846, p1921-1926. 6p. 2 Diagrams, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Giardia+lamblia%22">Giardia lamblia</searchLink><br /><searchLink fieldCode="DE" term="%22Eukaryotic+cells%22">Eukaryotic cells</searchLink><br /><searchLink fieldCode="DE" term="%22Intestinal+parasites%22">Intestinal parasites</searchLink><br /><searchLink fieldCode="DE" term="%22Introns%22">Introns</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondrial+pathology%22">Mitochondrial pathology</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+replication%22">DNA replication</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Archaebacteria%22">Archaebacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Heterozygosity%22">Heterozygosity</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity, supporting recent speculations that this organism is sexual. This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=26973508
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        Value: 10.1126/science.1143837
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        Text: English
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      – SubjectFull: Giardia lamblia
        Type: general
      – SubjectFull: Eukaryotic cells
        Type: general
      – SubjectFull: Intestinal parasites
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      – SubjectFull: Introns
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      – SubjectFull: Protein kinases
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