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Role of GABA in anxiety and depression.

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Title: Role of GABA in anxiety and depression.
Authors: Kalueff, Allan V., Nutt, David J.
Source: Depression & Anxiety (1091-4269). 2007, Vol. 24 Issue 7, p495-517. 23p. 2 Diagrams, 6 Charts.
Subjects: GABA, Anxiety, Mental depression, Neurotransmitters, Neuropsychiatry, Amino acid neurotransmitters
Abstract: This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed. Depression Anxiety 24:495–517, 2007. Published © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Role of GABA in anxiety and depression.
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  Data: <searchLink fieldCode="AR" term="%22Kalueff%2C+Allan+V%2E%22">Kalueff, Allan V.</searchLink><br /><searchLink fieldCode="AR" term="%22Nutt%2C+David+J%2E%22">Nutt, David J.</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22GABA%22">GABA</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychiatry%22">Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acid+neurotransmitters%22">Amino acid neurotransmitters</searchLink>
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  Data: This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed. Depression Anxiety 24:495–517, 2007. Published © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=26976954
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        Value: 10.1002/da.20262
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        Text: English
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      – SubjectFull: GABA
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Neurotransmitters
        Type: general
      – SubjectFull: Neuropsychiatry
        Type: general
      – SubjectFull: Amino acid neurotransmitters
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      – TitleFull: Role of GABA in anxiety and depression.
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