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Safety of the RTS, S/AAO2D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIIb trial.

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Title: Safety of the RTS, S/AAO2D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIIb trial.
Authors: Aponte, John L., Aide, Pedro, Renom, Montse, Mandomando, Inacio, Bassat, Quique, Sacarlal, Jahit, Manaca, M. Nelia, Lafuente, Sarah, Barbosa, Arnoldo, Leach, Amanda, Lievens, Marc, Vekemans, Johan, Sigauque, Beteul, Dubois, Marie-Claude, Demoitié, Marie-Ange, Sillman, Marla, Savarese, Barbara, McNeil, John G., Macete, Eusebio, Ballou, W. Ripley
Source: Lancet. 11/3/2007, Vol. 370 Issue 9598, p1543-1551. 9p. 1 Diagram, 3 Charts, 2 Graphs.
Subjects: Clinical trial registries, Malaria vaccines, Protozoan vaccines, Clinical drug trials, Plasmodium falciparum, Vaccination of infants, Health outcome assessment, Vaccination
Geographic Terms: Mozambique
Abstract: This article presents the results of a clinical trial of the RTS,S/ASO2D candidate malaria vaccine in infants in a highly infected area of Mozambique. Malaria is a huge global health problem and efforts to wipe out the disease have not been successful so the introduction of new control methods are needed. The vaccine RTS,S specifically targets the pre-erythrocytic stage of the Plasmodium falciparum and has show complete or partial protection in adults. This study wanted to see how effective the candidate vaccine would be in infants with the intent to register the vaccine for use in children living in endemic malarial areas. The study found the RTS,S/ASO2D vaccine to be safe, well tolerated and immunogenic in young infants which allows for phase III trials on the vaccine.
Database: Psychology and Behavioral Sciences Collection
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  Availability: 0
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Safety of the RTS, S/AAO2D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIIb trial.
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  Data: <searchLink fieldCode="AR" term="%22Aponte%2C+John+L%2E%22">Aponte, John L.</searchLink><br /><searchLink fieldCode="AR" term="%22Aide%2C+Pedro%22">Aide, Pedro</searchLink><br /><searchLink fieldCode="AR" term="%22Renom%2C+Montse%22">Renom, Montse</searchLink><br /><searchLink fieldCode="AR" term="%22Mandomando%2C+Inacio%22">Mandomando, Inacio</searchLink><br /><searchLink fieldCode="AR" term="%22Bassat%2C+Quique%22">Bassat, Quique</searchLink><br /><searchLink fieldCode="AR" term="%22Sacarlal%2C+Jahit%22">Sacarlal, Jahit</searchLink><br /><searchLink fieldCode="AR" term="%22Manaca%2C+M%2E+Nelia%22">Manaca, M. Nelia</searchLink><br /><searchLink fieldCode="AR" term="%22Lafuente%2C+Sarah%22">Lafuente, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Barbosa%2C+Arnoldo%22">Barbosa, Arnoldo</searchLink><br /><searchLink fieldCode="AR" term="%22Leach%2C+Amanda%22">Leach, Amanda</searchLink><br /><searchLink fieldCode="AR" term="%22Lievens%2C+Marc%22">Lievens, Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Vekemans%2C+Johan%22">Vekemans, Johan</searchLink><br /><searchLink fieldCode="AR" term="%22Sigauque%2C+Beteul%22">Sigauque, Beteul</searchLink><br /><searchLink fieldCode="AR" term="%22Dubois%2C+Marie-Claude%22">Dubois, Marie-Claude</searchLink><br /><searchLink fieldCode="AR" term="%22Demoitié%2C+Marie-Ange%22">Demoitié, Marie-Ange</searchLink><br /><searchLink fieldCode="AR" term="%22Sillman%2C+Marla%22">Sillman, Marla</searchLink><br /><searchLink fieldCode="AR" term="%22Savarese%2C+Barbara%22">Savarese, Barbara</searchLink><br /><searchLink fieldCode="AR" term="%22McNeil%2C+John+G%2E%22">McNeil, John G.</searchLink><br /><searchLink fieldCode="AR" term="%22Macete%2C+Eusebio%22">Macete, Eusebio</searchLink><br /><searchLink fieldCode="AR" term="%22Ballou%2C+W%2E+Ripley%22">Ballou, W. Ripley</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 11/3/2007, Vol. 370 Issue 9598, p1543-1551. 9p. 1 Diagram, 3 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Clinical+trial+registries%22">Clinical trial registries</searchLink><br /><searchLink fieldCode="DE" term="%22Malaria+vaccines%22">Malaria vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Protozoan+vaccines%22">Protozoan vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+drug+trials%22">Clinical drug trials</searchLink><br /><searchLink fieldCode="DE" term="%22Plasmodium+falciparum%22">Plasmodium falciparum</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccination+of+infants%22">Vaccination of infants</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccination%22">Vaccination</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22Mozambique%22">Mozambique</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This article presents the results of a clinical trial of the RTS,S/ASO2D candidate malaria vaccine in infants in a highly infected area of Mozambique. Malaria is a huge global health problem and efforts to wipe out the disease have not been successful so the introduction of new control methods are needed. The vaccine RTS,S specifically targets the pre-erythrocytic stage of the Plasmodium falciparum and has show complete or partial protection in adults. This study wanted to see how effective the candidate vaccine would be in infants with the intent to register the vaccine for use in children living in endemic malarial areas. The study found the RTS,S/ASO2D vaccine to be safe, well tolerated and immunogenic in young infants which allows for phase III trials on the vaccine.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=27433051
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/S0140-6736(07)61542-6
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 1543
    Subjects:
      – SubjectFull: Clinical trial registries
        Type: general
      – SubjectFull: Malaria vaccines
        Type: general
      – SubjectFull: Protozoan vaccines
        Type: general
      – SubjectFull: Clinical drug trials
        Type: general
      – SubjectFull: Plasmodium falciparum
        Type: general
      – SubjectFull: Vaccination of infants
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      – SubjectFull: Health outcome assessment
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      – SubjectFull: Vaccination
        Type: general
      – SubjectFull: Mozambique
        Type: general
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      – TitleFull: Safety of the RTS, S/AAO2D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIIb trial.
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              Text: 11/3/2007
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