Ischaemic stroke – impact of renal dysfunction on in-hospital mortality.
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| Title: | Ischaemic stroke – impact of renal dysfunction on in-hospital mortality. |
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| Authors: | Fabjan, T. Hojs, Hojs, R., Tetičkovi, E., Balon, B. Pečovnik |
| Source: | European Journal of Neurology. Dec2007, Vol. 14 Issue 12, p1351-1356. 6p. 1 Chart. |
| Subjects: | Cerebrovascular disease, Coronary disease, Myocardial infarction, Glomerular filtration rate, Diabetes, Hypertension, Patients |
| Abstract: | Renal dysfunction predicts mortality in patients with myocardial infarction but less is known about the impact of renal dysfunction on in-hospital mortality after ischaemic stroke. All 361 patients (185 men, 176 women; mean age 72.1 years) with ischaemic stroke and glomerular filtration rate (GFR) <90 ml/min/1.73 m2 were followed-up. GFR was calculated according to abbreviated modification of diet in renal disease (MDRD) formula. Stroke severity was determined by National Institutes of Health Stroke Scale (NIHSS). The mean GFR was 61.5 ± 16.6 ml/min/1.73 m2. There were 49 (13.6%) in-hospital deaths. Patients who died had higher NIHSS ( P = 0.0001), were older ( P = 0.024), had lower GFR ( P = 0.028), higher hs-C-reactive protein ( P = 0.001) and lower albumin ( P = 0.048). No differences in presence of diabetes and hypertension, cholesterol (total, HDL and LDL), triglycerides and BMI between patients who died or survived were found. With univariate analysis association between in-hospital mortality and NIHSS ( P = 0.0001), GFR ( P = 0.041), total cholesterol ( P = 0.021) and LDL cholesterol ( P = 0.034) was found. With Cox multivariable regression analysis of risk factors, NIHSS ( P = 0.0001), GFR ( P = 0.018), total cholesterol ( P = 0.008) and LDL cholesterol ( P = 0.011) were only predictors of in-hospital mortality. In patients with ischaemic stroke, decreased GFR was associated with higher in-hospital mortality. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 27476993 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ischaemic stroke – impact of renal dysfunction on in-hospital mortality. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fabjan%2C+T%2E+Hojs%22">Fabjan, T. Hojs</searchLink><br /><searchLink fieldCode="AR" term="%22Hojs%2C+R%2E%22">Hojs, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Tetičkovi%2C+E%2E%22">Tetičkovi, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Balon%2C+B%2E+Pečovnik%22">Balon, B. Pečovnik</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Dec2007, Vol. 14 Issue 12, p1351-1356. 6p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cerebrovascular+disease%22">Cerebrovascular disease</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+disease%22">Coronary disease</searchLink><br /><searchLink fieldCode="DE" term="%22Myocardial+infarction%22">Myocardial infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Glomerular+filtration+rate%22">Glomerular filtration rate</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes%22">Diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Renal dysfunction predicts mortality in patients with myocardial infarction but less is known about the impact of renal dysfunction on in-hospital mortality after ischaemic stroke. All 361 patients (185 men, 176 women; mean age 72.1 years) with ischaemic stroke and glomerular filtration rate (GFR) <90 ml/min/1.73 m2 were followed-up. GFR was calculated according to abbreviated modification of diet in renal disease (MDRD) formula. Stroke severity was determined by National Institutes of Health Stroke Scale (NIHSS). The mean GFR was 61.5 ± 16.6 ml/min/1.73 m2. There were 49 (13.6%) in-hospital deaths. Patients who died had higher NIHSS ( P = 0.0001), were older ( P = 0.024), had lower GFR ( P = 0.028), higher hs-C-reactive protein ( P = 0.001) and lower albumin ( P = 0.048). No differences in presence of diabetes and hypertension, cholesterol (total, HDL and LDL), triglycerides and BMI between patients who died or survived were found. With univariate analysis association between in-hospital mortality and NIHSS ( P = 0.0001), GFR ( P = 0.041), total cholesterol ( P = 0.021) and LDL cholesterol ( P = 0.034) was found. With Cox multivariable regression analysis of risk factors, NIHSS ( P = 0.0001), GFR ( P = 0.018), total cholesterol ( P = 0.008) and LDL cholesterol ( P = 0.011) were only predictors of in-hospital mortality. In patients with ischaemic stroke, decreased GFR was associated with higher in-hospital mortality. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1468-1331.2007.01976.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1351 Subjects: – SubjectFull: Cerebrovascular disease Type: general – SubjectFull: Coronary disease Type: general – SubjectFull: Myocardial infarction Type: general – SubjectFull: Glomerular filtration rate Type: general – SubjectFull: Diabetes Type: general – SubjectFull: Hypertension Type: general – SubjectFull: Patients Type: general Titles: – TitleFull: Ischaemic stroke – impact of renal dysfunction on in-hospital mortality. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fabjan, T. Hojs – PersonEntity: Name: NameFull: Hojs, R. – PersonEntity: Name: NameFull: Tetičkovi, E. – PersonEntity: Name: NameFull: Balon, B. Pečovnik IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 14 – Type: issue Value: 12 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
