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Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.

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Title: Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.
Authors: Keech, A.C., Mitchell, P., Summanen, P.A., O'Day, J., Davis, T.M.E., Moffitt, M.S., Taskinen, M-R., Simes, R.J., Tse, D., Williamson, E., Merrifield, A., Laatikainen, L.T., d'Emden, M.C., Crimet, D.C., O'Connell, R.L., Colman, P.G.
Source: Lancet. 11/17/2007, Vol. 370 Issue 9600, p1687-1697. 11p. 1 Diagram, 5 Charts, 6 Graphs.
Subjects: Clinical trial registries, Diabetic retinopathy treatment, Fenofibrate, Treatment of eye diseases, Retinal diseases, Diabetes complications, Laser surgery, Antilipemic agents, Blood pressure, Blood sugar, Blood lipids, Health outcome assessment
Abstract: This article presents the results of a study to see if long-term lipid-lowering therapy with fenofibrate could reduce the progression of diabetic retinopathy and the need for laser treatment in diabetic patients. Diabetic retinopathy is the leading cause of vision loss in adults with type 2 diabetes and the normal treatment is with laser. While this treatment works on slowing the progression of the disease it has some ocular side effects. The study found that laser treatment was needed more often in patients with poor glycaemic or blood pressure control and in those with microvascular disease. Treatment with fenofibrate was found to reduce the need for laser treatment but does not seem to be related to blood lipids.
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 27596556
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.
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  Data: <searchLink fieldCode="AR" term="%22Keech%2C+A%2EC%2E%22">Keech, A.C.</searchLink><br /><searchLink fieldCode="AR" term="%22Mitchell%2C+P%2E%22">Mitchell, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Summanen%2C+P%2EA%2E%22">Summanen, P.A.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Day%2C+J%2E%22">O'Day, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+T%2EM%2EE%2E%22">Davis, T.M.E.</searchLink><br /><searchLink fieldCode="AR" term="%22Moffitt%2C+M%2ES%2E%22">Moffitt, M.S.</searchLink><br /><searchLink fieldCode="AR" term="%22Taskinen%2C+M-R%2E%22">Taskinen, M-R.</searchLink><br /><searchLink fieldCode="AR" term="%22Simes%2C+R%2EJ%2E%22">Simes, R.J.</searchLink><br /><searchLink fieldCode="AR" term="%22Tse%2C+D%2E%22">Tse, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Williamson%2C+E%2E%22">Williamson, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Merrifield%2C+A%2E%22">Merrifield, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Laatikainen%2C+L%2ET%2E%22">Laatikainen, L.T.</searchLink><br /><searchLink fieldCode="AR" term="%22d'Emden%2C+M%2EC%2E%22">d'Emden, M.C.</searchLink><br /><searchLink fieldCode="AR" term="%22Crimet%2C+D%2EC%2E%22">Crimet, D.C.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Connell%2C+R%2EL%2E%22">O'Connell, R.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Colman%2C+P%2EG%2E%22">Colman, P.G.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 11/17/2007, Vol. 370 Issue 9600, p1687-1697. 11p. 1 Diagram, 5 Charts, 6 Graphs.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Clinical+trial+registries%22">Clinical trial registries</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetic+retinopathy+treatment%22">Diabetic retinopathy treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Fenofibrate%22">Fenofibrate</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+eye+diseases%22">Treatment of eye diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+diseases%22">Retinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+complications%22">Diabetes complications</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+surgery%22">Laser surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Antilipemic+agents%22">Antilipemic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar%22">Blood sugar</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+lipids%22">Blood lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This article presents the results of a study to see if long-term lipid-lowering therapy with fenofibrate could reduce the progression of diabetic retinopathy and the need for laser treatment in diabetic patients. Diabetic retinopathy is the leading cause of vision loss in adults with type 2 diabetes and the normal treatment is with laser. While this treatment works on slowing the progression of the disease it has some ocular side effects. The study found that laser treatment was needed more often in patients with poor glycaemic or blood pressure control and in those with microvascular disease. Treatment with fenofibrate was found to reduce the need for laser treatment but does not seem to be related to blood lipids.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=27596556
RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.1016/S0140-6736(07)61607-9
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 1687
    Subjects:
      – SubjectFull: Clinical trial registries
        Type: general
      – SubjectFull: Diabetic retinopathy treatment
        Type: general
      – SubjectFull: Fenofibrate
        Type: general
      – SubjectFull: Treatment of eye diseases
        Type: general
      – SubjectFull: Retinal diseases
        Type: general
      – SubjectFull: Diabetes complications
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      – SubjectFull: Laser surgery
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      – SubjectFull: Antilipemic agents
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      – SubjectFull: Blood sugar
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      – SubjectFull: Blood lipids
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      – SubjectFull: Health outcome assessment
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      – TitleFull: Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.
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              Text: 11/17/2007
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