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Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.

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Title: Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.
Authors: Chi, Benjamin H., Sinkala, Moses, Mbewe, Felistas, Cantrell, Ronald A., Kruse, Gina, Chintu, Namwinga, Aldrovandi, Grace M., Stringer, Elizabeth M., Kankasa, Chipepo, Safrit, Jeffrey T., Stringer, Jeffrey S.A.
Source: Lancet. 11/17/2007, Vol. 370 Issue 9600, p1698-1705. 8p. 1 Diagram, 4 Charts, 2 Graphs.
Subjects: Clinical trial registries, HIV prevention, Prenatal care, Perinatal pharmacology, Prevention of communicable diseases, Drug resistance, Delivery (Obstetrics), Health outcome assessment, Nevirapine, Tenofovir, Emtricitabine, HIV-positive women, HIV infection transmission, Prevention, Therapeutics
Abstract: This article reports on a study looking to see if a single treatment with tenofovir and emtricitabine might be able to be added to the dose of nevirapine given for the prevention of HIV transmission during labor to poor women in developing countries. Nevirapine is the normal treatment but it has been shown to produce a resistance to other non-nucleoside reverse transcriptase inhibitor drugs. This study wanted to see if the drugs, administered during labor, would reverse the adverse effects of nevirapine without compromising its effectiveness. The study found that the single dose of tenofovir and emtricitabine at delivery reduced drug resistance by half at 6 weeks after delivery and the authors suggest it should be added to the nevirapine therapy.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 27596557
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.
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  Data: <searchLink fieldCode="AR" term="%22Chi%2C+Benjamin+H%2E%22">Chi, Benjamin H.</searchLink><br /><searchLink fieldCode="AR" term="%22Sinkala%2C+Moses%22">Sinkala, Moses</searchLink><br /><searchLink fieldCode="AR" term="%22Mbewe%2C+Felistas%22">Mbewe, Felistas</searchLink><br /><searchLink fieldCode="AR" term="%22Cantrell%2C+Ronald+A%2E%22">Cantrell, Ronald A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kruse%2C+Gina%22">Kruse, Gina</searchLink><br /><searchLink fieldCode="AR" term="%22Chintu%2C+Namwinga%22">Chintu, Namwinga</searchLink><br /><searchLink fieldCode="AR" term="%22Aldrovandi%2C+Grace+M%2E%22">Aldrovandi, Grace M.</searchLink><br /><searchLink fieldCode="AR" term="%22Stringer%2C+Elizabeth+M%2E%22">Stringer, Elizabeth M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kankasa%2C+Chipepo%22">Kankasa, Chipepo</searchLink><br /><searchLink fieldCode="AR" term="%22Safrit%2C+Jeffrey+T%2E%22">Safrit, Jeffrey T.</searchLink><br /><searchLink fieldCode="AR" term="%22Stringer%2C+Jeffrey+S%2EA%2E%22">Stringer, Jeffrey S.A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 11/17/2007, Vol. 370 Issue 9600, p1698-1705. 8p. 1 Diagram, 4 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Clinical+trial+registries%22">Clinical trial registries</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+prevention%22">HIV prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+care%22">Prenatal care</searchLink><br /><searchLink fieldCode="DE" term="%22Perinatal+pharmacology%22">Perinatal pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention+of+communicable+diseases%22">Prevention of communicable diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Delivery+%28Obstetrics%29%22">Delivery (Obstetrics)</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Nevirapine%22">Nevirapine</searchLink><br /><searchLink fieldCode="DE" term="%22Tenofovir%22">Tenofovir</searchLink><br /><searchLink fieldCode="DE" term="%22Emtricitabine%22">Emtricitabine</searchLink><br /><searchLink fieldCode="DE" term="%22HIV-positive+women%22">HIV-positive women</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infection+transmission%22">HIV infection transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This article reports on a study looking to see if a single treatment with tenofovir and emtricitabine might be able to be added to the dose of nevirapine given for the prevention of HIV transmission during labor to poor women in developing countries. Nevirapine is the normal treatment but it has been shown to produce a resistance to other non-nucleoside reverse transcriptase inhibitor drugs. This study wanted to see if the drugs, administered during labor, would reverse the adverse effects of nevirapine without compromising its effectiveness. The study found that the single dose of tenofovir and emtricitabine at delivery reduced drug resistance by half at 6 weeks after delivery and the authors suggest it should be added to the nevirapine therapy.
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(07)61605-5
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1698
    Subjects:
      – SubjectFull: Clinical trial registries
        Type: general
      – SubjectFull: HIV prevention
        Type: general
      – SubjectFull: Prenatal care
        Type: general
      – SubjectFull: Perinatal pharmacology
        Type: general
      – SubjectFull: Prevention of communicable diseases
        Type: general
      – SubjectFull: Drug resistance
        Type: general
      – SubjectFull: Delivery (Obstetrics)
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Nevirapine
        Type: general
      – SubjectFull: Tenofovir
        Type: general
      – SubjectFull: Emtricitabine
        Type: general
      – SubjectFull: HIV-positive women
        Type: general
      – SubjectFull: HIV infection transmission
        Type: general
      – SubjectFull: Prevention
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.
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              Text: 11/17/2007
              Type: published
              Y: 2007
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              Value: 370
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