Impact of Treatment of Gastroesophageal Reflux on Obstructive Sleep Apnea-Hypopnea Syndrome.
Saved in:
| Title: | Impact of Treatment of Gastroesophageal Reflux on Obstructive Sleep Apnea-Hypopnea Syndrome. |
|---|---|
| Authors: | Friedman, Michael, Gurpinar, Berk, Hsin-Ching Lin, Schalch, Paul, Joseph, Ninos J. |
| Source: | Annals of Otology, Rhinology & Laryngology. Nov2007, Vol. 116 Issue 11, p805-811. 7p. |
| Subjects: | Gastroesophageal reflux, Sleep apnea syndrome treatment, Sleep disorder diagnosis, Esophagus diseases, Clinical medicine, Medical research |
| Abstract: | Objectives: We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at the upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, and quality-of-life surveys were completed for each patient. Patients who tested positive for GERD were treated with esomeprazole magnesium 40 mg once daily for 2 to 12 months. The 24-hour pH study was repeated, and those patients with elimination of GERD were reevaluated by polysomnography, snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys, and subjective data collection. Results: Forty-one patients completed single-dose treatment with esomeprazole, but the repeat 24-hour pH study showed that 9 patients had persistent GERD. In the 29 patients who completed phase 2 with normal pH study findings, the snoring level decreased from 9.7 ± 0.5 to 7.9 ± 1.3 (p < .0001), the Epworth Sleepiness Scale score decreased from 14.2 ± 2.5 to 11.1 ± 2.4 (p < .0001), the apnea-hypopnea index decreased from 37.9 ± 19.1 to 28.8 ± 11.5 (p = .006), and the minimum saturation of oxygen increased from 84.1% ± 7.8% to 86.9% ± 5.0% (p = .055). Conclusions: Treatment of GERD had a significant impact on the reduction of the apnea-hypopnea index, snoring, and daytime sleepiness. Elimination of GERD should be part of a comprehensive treatment plan for patients with OSAHS. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 27661556 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Impact of Treatment of Gastroesophageal Reflux on Obstructive Sleep Apnea-Hypopnea Syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Friedman%2C+Michael%22">Friedman, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Gurpinar%2C+Berk%22">Gurpinar, Berk</searchLink><br /><searchLink fieldCode="AR" term="%22Hsin-Ching+Lin%22">Hsin-Ching Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Schalch%2C+Paul%22">Schalch, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Joseph%2C+Ninos+J%2E%22">Joseph, Ninos J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Nov2007, Vol. 116 Issue 11, p805-811. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gastroesophageal+reflux%22">Gastroesophageal reflux</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+apnea+syndrome+treatment%22">Sleep apnea syndrome treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorder+diagnosis%22">Sleep disorder diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Esophagus+diseases%22">Esophagus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+medicine%22">Clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at the upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, and quality-of-life surveys were completed for each patient. Patients who tested positive for GERD were treated with esomeprazole magnesium 40 mg once daily for 2 to 12 months. The 24-hour pH study was repeated, and those patients with elimination of GERD were reevaluated by polysomnography, snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys, and subjective data collection. Results: Forty-one patients completed single-dose treatment with esomeprazole, but the repeat 24-hour pH study showed that 9 patients had persistent GERD. In the 29 patients who completed phase 2 with normal pH study findings, the snoring level decreased from 9.7 ± 0.5 to 7.9 ± 1.3 (p < .0001), the Epworth Sleepiness Scale score decreased from 14.2 ± 2.5 to 11.1 ± 2.4 (p < .0001), the apnea-hypopnea index decreased from 37.9 ± 19.1 to 28.8 ± 11.5 (p = .006), and the minimum saturation of oxygen increased from 84.1% ± 7.8% to 86.9% ± 5.0% (p = .055). Conclusions: Treatment of GERD had a significant impact on the reduction of the apnea-hypopnea index, snoring, and daytime sleepiness. Elimination of GERD should be part of a comprehensive treatment plan for patients with OSAHS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=27661556 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/000348940711601103 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 805 Subjects: – SubjectFull: Gastroesophageal reflux Type: general – SubjectFull: Sleep apnea syndrome treatment Type: general – SubjectFull: Sleep disorder diagnosis Type: general – SubjectFull: Esophagus diseases Type: general – SubjectFull: Clinical medicine Type: general – SubjectFull: Medical research Type: general Titles: – TitleFull: Impact of Treatment of Gastroesophageal Reflux on Obstructive Sleep Apnea-Hypopnea Syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Friedman, Michael – PersonEntity: Name: NameFull: Gurpinar, Berk – PersonEntity: Name: NameFull: Hsin-Ching Lin – PersonEntity: Name: NameFull: Schalch, Paul – PersonEntity: Name: NameFull: Joseph, Ninos J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00034894 Numbering: – Type: volume Value: 116 – Type: issue Value: 11 Titles: – TitleFull: Annals of Otology, Rhinology & Laryngology Type: main |
| ResultId | 1 |
