MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury.
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| Title: | MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. |
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| Authors: | Sturzenegger, M., Radanov, B. P., Winter, P., Simko, M., Farra, A. D., Di Stefano, G. |
| Source: | Acta Neurologica Scandinavica. Jan2008, Vol. 117 Issue 1, p49-54. 6p. 2 Black and White Photographs, 3 Charts. |
| Subjects: | Memory disorders, Attention, Whiplash injuries, Magnetic resonance imaging, Neuropsychology, Complications of brain injuries |
| Abstract: | Introduction – Cognitive complaints, such as poor concentration and memory deficits, are frequent after whiplash injury and play an important role in disability. The origin of these complaints is discussed controversially. Some authors postulate brain lesions as a consequence of whiplash injuries. Potential diffuse axonal injury (DAI) with subsequent atrophy of the brain and ventricular expansion is of particular interest as focal brain lesions have not been documented so far in whiplash injury. Objective – To investigate whether traumatic brain injury can be identified using a magnetic resonance (MR)-based quantitative analysis of normalized ventricle–brain ratios (VBR) in chronic whiplash patients with subjective cognitive impairment that cannot be objectively confirmed by neuropsychological testing. Materials and methods – MR examination was performed in 21 patients with whiplash injury and symptom persistence for 9 months on average and in 18 matched healthy controls. Conventional MR imaging (MRI) was used to assess the volumes of grey and white matter and of ventricles. The normalized VBR was calculated. Results – The values of normalized VBR did not differ in whiplash patients when compared with that in healthy controls ( F = 0.216, P = 0.645). Conclusions – This study does not support loss of brain tissue following whiplash injury as measured by VBR. On this basis, traumatic brain injury with subsequent DAI does not seem to be the underlying mechanism for persistent concentration and memory deficits that are subjectively reported but not objectively verifiable as neuropsychological deficits. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 27810967 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sturzenegger%2C+M%2E%22">Sturzenegger, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Radanov%2C+B%2E+P%2E%22">Radanov, B. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Winter%2C+P%2E%22">Winter, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Simko%2C+M%2E%22">Simko, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Farra%2C+A%2E+D%2E%22">Farra, A. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Stefano%2C+G%2E%22">Di Stefano, G.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jan2008, Vol. 117 Issue 1, p49-54. 6p. 2 Black and White Photographs, 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Memory+disorders%22">Memory disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Attention%22">Attention</searchLink><br /><searchLink fieldCode="DE" term="%22Whiplash+injuries%22">Whiplash injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Complications+of+brain+injuries%22">Complications of brain injuries</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction – Cognitive complaints, such as poor concentration and memory deficits, are frequent after whiplash injury and play an important role in disability. The origin of these complaints is discussed controversially. Some authors postulate brain lesions as a consequence of whiplash injuries. Potential diffuse axonal injury (DAI) with subsequent atrophy of the brain and ventricular expansion is of particular interest as focal brain lesions have not been documented so far in whiplash injury. Objective – To investigate whether traumatic brain injury can be identified using a magnetic resonance (MR)-based quantitative analysis of normalized ventricle–brain ratios (VBR) in chronic whiplash patients with subjective cognitive impairment that cannot be objectively confirmed by neuropsychological testing. Materials and methods – MR examination was performed in 21 patients with whiplash injury and symptom persistence for 9 months on average and in 18 matched healthy controls. Conventional MR imaging (MRI) was used to assess the volumes of grey and white matter and of ventricles. The normalized VBR was calculated. Results – The values of normalized VBR did not differ in whiplash patients when compared with that in healthy controls ( F = 0.216, P = 0.645). Conclusions – This study does not support loss of brain tissue following whiplash injury as measured by VBR. On this basis, traumatic brain injury with subsequent DAI does not seem to be the underlying mechanism for persistent concentration and memory deficits that are subjectively reported but not objectively verifiable as neuropsychological deficits. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1600-0404.2007.00939.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 49 Subjects: – SubjectFull: Memory disorders Type: general – SubjectFull: Attention Type: general – SubjectFull: Whiplash injuries Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Neuropsychology Type: general – SubjectFull: Complications of brain injuries Type: general Titles: – TitleFull: MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sturzenegger, M. – PersonEntity: Name: NameFull: Radanov, B. P. – PersonEntity: Name: NameFull: Winter, P. – PersonEntity: Name: NameFull: Simko, M. – PersonEntity: Name: NameFull: Farra, A. D. – PersonEntity: Name: NameFull: Di Stefano, G. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 117 – Type: issue Value: 1 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
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