View in EDS HTML Full Text PDF Full Text

Indinavir concentrations and St John's wort.

Saved in:
Bibliographic Details
Title: Indinavir concentrations and St John's wort.
Authors: Piscitelli, Stephen C., Burstein, Aaron H., Chaitt, Doreen, Alfaro, Raul M., Falloon, Judith
Source: Lancet. 2/12/2000, Vol. 355 Issue 9203, p547. 2p. 1 Graph.
Subjects: Hypericum perforatum, Hypericum, HIV, National Institute of Allergy & Infectious Diseases (U.S.), Testing, Therapeutics
Geographic Terms: United Kingdom
Abstract: St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 2798028
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Indinavir concentrations and St John's wort.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Piscitelli%2C+Stephen+C%2E%22">Piscitelli, Stephen C.</searchLink><br /><searchLink fieldCode="AR" term="%22Burstein%2C+Aaron+H%2E%22">Burstein, Aaron H.</searchLink><br /><searchLink fieldCode="AR" term="%22Chaitt%2C+Doreen%22">Chaitt, Doreen</searchLink><br /><searchLink fieldCode="AR" term="%22Alfaro%2C+Raul+M%2E%22">Alfaro, Raul M.</searchLink><br /><searchLink fieldCode="AR" term="%22Falloon%2C+Judith%22">Falloon, Judith</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 2/12/2000, Vol. 355 Issue 9203, p547. 2p. 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hypericum+perforatum%22">Hypericum perforatum</searchLink><br /><searchLink fieldCode="DE" term="%22Hypericum%22">Hypericum</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22National+Institute+of+Allergy+%26+Infectious+Diseases+%28U%2ES%2E%29%22">National Institute of Allergy & Infectious Diseases (U.S.)</searchLink><br /><searchLink fieldCode="DE" term="%22Testing%22">Testing</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=2798028
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(99)05712-8
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 2
        StartPage: 547
    Subjects:
      – SubjectFull: Hypericum perforatum
        Type: general
      – SubjectFull: Hypericum
        Type: general
      – SubjectFull: HIV
        Type: general
      – SubjectFull: National Institute of Allergy & Infectious Diseases (U.S.)
        Type: general
      – SubjectFull: Testing
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: United Kingdom
        Type: general
    Titles:
      – TitleFull: Indinavir concentrations and St John's wort.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Piscitelli, Stephen C.
      – PersonEntity:
          Name:
            NameFull: Burstein, Aaron H.
      – PersonEntity:
          Name:
            NameFull: Chaitt, Doreen
      – PersonEntity:
          Name:
            NameFull: Alfaro, Raul M.
      – PersonEntity:
          Name:
            NameFull: Falloon, Judith
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 02
              Text: 2/12/2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 355
            – Type: issue
              Value: 9203
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1