Intralesional recordings and epileptogenic zone in focal polymicrogyria.
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| Title: | Intralesional recordings and epileptogenic zone in focal polymicrogyria. |
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| Authors: | Chassoux, Francine, Landre, Elisabeth, Rodrigo, Sebastian, Beuvon, Frédéric, Turak, Baris, Semah, Franck, Devaux, Bertrand |
| Source: | Epilepsia (Series 4). Jan2008, Vol. 49 Issue 1, p51-64. 14p. 1 Chart. |
| Subjects: | Epilepsy, Brain diseases, Temporal lobe, Diagnostic imaging, Medical radiography |
| Abstract: | Polymicrogyria (PMG) is recognized as an epileptogenic lesion but few data concerning organization of the epileptogenic zone (EZ) are available. We analyzed the distribution of the EZ according to Stereo-EEG (SEEG) with intralesional recordings in four patients evaluated for intractable partial epilepsy associated with focal unilateral PMG, involving the posterior temporal region in two, the perisylvian area in one and the temporoparietal junction in the other. All had ictal scalp EEG, high-resolution structural and functional MRI, fluorodeoxyglucose positron emission tomography (FDG-PET), and SEEG. For each patient, several depth electrodes were implanted both within the PMG and in extralesional areas. In three patients, the PMG displayed high-frequency spiking activity. However, interictal and ictal recordings demonstrated a large epileptogenic network, which was more widespread than the PMG, including the mesial temporal structures in two. In another patient, interictal spiking and seizure onset site were located within the hippocampus and outside of the PMG, although it was rapidly involved during seizure spread. Overall, EZ was considered to be larger than the PMG in all patients although hypometabolic areas detected by PET were concordant with EZ. Three patients underwent extensive surgery including the PMG and are seizure free with a follow-up >2 years. Although intralesional recordings demonstrated intrinsic epileptogenicity in PMG, our data provide evidence that unilateral focal PMG belongs to a large epileptogenic network extending beyond the MRI lesion. SEEG may be helpful for planning surgery with favorable outcome, providing large resections are feasible, even in apparently focal PMG. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 28024993 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intralesional recordings and epileptogenic zone in focal polymicrogyria. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chassoux%2C+Francine%22">Chassoux, Francine</searchLink><br /><searchLink fieldCode="AR" term="%22Landre%2C+Elisabeth%22">Landre, Elisabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Rodrigo%2C+Sebastian%22">Rodrigo, Sebastian</searchLink><br /><searchLink fieldCode="AR" term="%22Beuvon%2C+Frédéric%22">Beuvon, Frédéric</searchLink><br /><searchLink fieldCode="AR" term="%22Turak%2C+Baris%22">Turak, Baris</searchLink><br /><searchLink fieldCode="AR" term="%22Semah%2C+Franck%22">Semah, Franck</searchLink><br /><searchLink fieldCode="AR" term="%22Devaux%2C+Bertrand%22">Devaux, Bertrand</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jan2008, Vol. 49 Issue 1, p51-64. 14p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+diseases%22">Brain diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+radiography%22">Medical radiography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Polymicrogyria (PMG) is recognized as an epileptogenic lesion but few data concerning organization of the epileptogenic zone (EZ) are available. We analyzed the distribution of the EZ according to Stereo-EEG (SEEG) with intralesional recordings in four patients evaluated for intractable partial epilepsy associated with focal unilateral PMG, involving the posterior temporal region in two, the perisylvian area in one and the temporoparietal junction in the other. All had ictal scalp EEG, high-resolution structural and functional MRI, fluorodeoxyglucose positron emission tomography (FDG-PET), and SEEG. For each patient, several depth electrodes were implanted both within the PMG and in extralesional areas. In three patients, the PMG displayed high-frequency spiking activity. However, interictal and ictal recordings demonstrated a large epileptogenic network, which was more widespread than the PMG, including the mesial temporal structures in two. In another patient, interictal spiking and seizure onset site were located within the hippocampus and outside of the PMG, although it was rapidly involved during seizure spread. Overall, EZ was considered to be larger than the PMG in all patients although hypometabolic areas detected by PET were concordant with EZ. Three patients underwent extensive surgery including the PMG and are seizure free with a follow-up >2 years. Although intralesional recordings demonstrated intrinsic epileptogenicity in PMG, our data provide evidence that unilateral focal PMG belongs to a large epileptogenic network extending beyond the MRI lesion. SEEG may be helpful for planning surgery with favorable outcome, providing large resections are feasible, even in apparently focal PMG. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1528-1167.2007.01267.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 51 Subjects: – SubjectFull: Epilepsy Type: general – SubjectFull: Brain diseases Type: general – SubjectFull: Temporal lobe Type: general – SubjectFull: Diagnostic imaging Type: general – SubjectFull: Medical radiography Type: general Titles: – TitleFull: Intralesional recordings and epileptogenic zone in focal polymicrogyria. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chassoux, Francine – PersonEntity: Name: NameFull: Landre, Elisabeth – PersonEntity: Name: NameFull: Rodrigo, Sebastian – PersonEntity: Name: NameFull: Beuvon, Frédéric – PersonEntity: Name: NameFull: Turak, Baris – PersonEntity: Name: NameFull: Semah, Franck – PersonEntity: Name: NameFull: Devaux, Bertrand IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 49 – Type: issue Value: 1 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
| ResultId | 1 |
