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Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression.

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Title: Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression.
Authors: Kim, Sung‐Wan (AUTHOR), Shin, Il‐Seon (AUTHOR), Kim, Jae‐Min (AUTHOR), Kim, Young‐Chul (AUTHOR), Kim, Kyu‐Sik (AUTHOR), Kim, Ki‐Min (AUTHOR), Yang, Su‐Jin (AUTHOR), Yoon, Jin‐Sang (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Feb2008, Vol. 62 Issue 1, p75-83. 9p. 3 Charts, 1 Graph.
Subjects: Cancer treatment, Cancer diagnosis, Insomnia, Nausea, Medical care research
Abstract: Aims: The purpose of the present paper was to evaluate the effectiveness of mirtazapine orally disintegrating tablets for nausea and sleep disturbance, which are common and distressing symptoms of cancer. Methods: This was a 4-week, prospective, open-labeled study of cancer patients. Assessments were performed at baseline and on days 1, 3, 5, 7, 14, and 28. Primary outcome measures were the Clinical Global Impression scale for nausea/vomiting and the Chonnam National University Hospital–Leeds Sleep Evaluation Questionnaire (C-LSEQ) including total amount of night sleep time. The secondary outcome measures consisted of pain items in the 36-item Short Form Health Survey, the Montgomery–Asberg Depression Rating Scale (MADRS), and the EuroQoL (EQ)-5D. Forty-two cancer patients were enrolled. Results: Those with nausea ( n = 28) improved significantly from day 1. The total night sleep time and each item on the C-LSEQ improved from days 1–5. The scores on the MADRS and the depression/anxiety dimension and visual analog scale of EQ-5D improved significantly from the first week. Pain measures also improved from day 1. Exacerbation of sleepiness developed in approximately one-third of subjects during the initial few days, but disappeared gradually. Conclusion: In the present study mirtazapine rapidly improved nausea, sleep disturbance, pain and quality of life, as well as depression in cancer patients. Mirtazapine may be an effective treatment option in managing cancer patients with multiple distressing symptoms, including nausea and sleep disturbance. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Sung‐Wan%22">Kim, Sung‐Wan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shin%2C+Il‐Seon%22">Shin, Il‐Seon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jae‐Min%22">Kim, Jae‐Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Young‐Chul%22">Kim, Young‐Chul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Kyu‐Sik%22">Kim, Kyu‐Sik</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Ki‐Min%22">Kim, Ki‐Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Su‐Jin%22">Yang, Su‐Jin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoon%2C+Jin‐Sang%22">Yoon, Jin‐Sang</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Feb2008, Vol. 62 Issue 1, p75-83. 9p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+diagnosis%22">Cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Insomnia%22">Insomnia</searchLink><br /><searchLink fieldCode="DE" term="%22Nausea%22">Nausea</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care+research%22">Medical care research</searchLink>
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  Label: Abstract
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  Data: Aims: The purpose of the present paper was to evaluate the effectiveness of mirtazapine orally disintegrating tablets for nausea and sleep disturbance, which are common and distressing symptoms of cancer. Methods: This was a 4-week, prospective, open-labeled study of cancer patients. Assessments were performed at baseline and on days 1, 3, 5, 7, 14, and 28. Primary outcome measures were the Clinical Global Impression scale for nausea/vomiting and the Chonnam National University Hospital–Leeds Sleep Evaluation Questionnaire (C-LSEQ) including total amount of night sleep time. The secondary outcome measures consisted of pain items in the 36-item Short Form Health Survey, the Montgomery–Asberg Depression Rating Scale (MADRS), and the EuroQoL (EQ)-5D. Forty-two cancer patients were enrolled. Results: Those with nausea ( n = 28) improved significantly from day 1. The total night sleep time and each item on the C-LSEQ improved from days 1–5. The scores on the MADRS and the depression/anxiety dimension and visual analog scale of EQ-5D improved significantly from the first week. Pain measures also improved from day 1. Exacerbation of sleepiness developed in approximately one-third of subjects during the initial few days, but disappeared gradually. Conclusion: In the present study mirtazapine rapidly improved nausea, sleep disturbance, pain and quality of life, as well as depression in cancer patients. Mirtazapine may be an effective treatment option in managing cancer patients with multiple distressing symptoms, including nausea and sleep disturbance. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1440-1819.2007.01778.x
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      – SubjectFull: Insomnia
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      – SubjectFull: Nausea
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      – TitleFull: Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression.
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              Text: Feb2008
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              Y: 2008
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