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Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy.

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Title: Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy.
Authors: Stemper, B., Devinsky, O., Haendl, T., Welsch, G., Hilz, M. J.
Source: Acta Neurologica Scandinavica. Apr2008, Vol. 117 Issue 4, p231-236. 6p. 2 Graphs.
Subjects: Neural stimulation, People with epilepsy, Heart rate monitoring, Respiration, Chronically ill
Abstract: Objective – To evaluate the impact of vagus nerve stimulation (VNS) on heart rate and blood pressure (BP) modulation in epilepsy patients. Material and methods – Twenty-one epilepsy patients with VNS were tested during on (60 s) and off (5 min) phases. We monitored BP, RR intervals (RRI) and respiration. Spectral analysis was performed in low- (LF: 0.04–0.15 Hz) and high-frequency bands (HF: 0.15–0.5 Hz). For coherences above 0.5, we calculated the LF transfer function between systolic BP and RRI, and the HF transfer function gain and phase between RRI and respiration. Differences between the on and off phases were evaluated using Wilcoxon test. Results – VNS did not change RRI and BP values. The LF power of BP and the LF and HF power of RRI increased significantly. There was a slight change in the RRI/BP LF gain and the RRI/respiration HF gain (ns). The HF phase between RRI and respiration decreased significantly. Conclusions – Our findings show that VNS influences both sympathetic and parasympathetic cardiovascular modulation. However, our results also show that VNS does not negatively influence autonomic cardiovascular regulation. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy.
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  Data: <searchLink fieldCode="AR" term="%22Stemper%2C+B%2E%22">Stemper, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Devinsky%2C+O%2E%22">Devinsky, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Haendl%2C+T%2E%22">Haendl, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Welsch%2C+G%2E%22">Welsch, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Hilz%2C+M%2E+J%2E%22">Hilz, M. J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Apr2008, Vol. 117 Issue 4, p231-236. 6p. 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+epilepsy%22">People with epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+rate+monitoring%22">Heart rate monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Respiration%22">Respiration</searchLink><br /><searchLink fieldCode="DE" term="%22Chronically+ill%22">Chronically ill</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective – To evaluate the impact of vagus nerve stimulation (VNS) on heart rate and blood pressure (BP) modulation in epilepsy patients. Material and methods – Twenty-one epilepsy patients with VNS were tested during on (60 s) and off (5 min) phases. We monitored BP, RR intervals (RRI) and respiration. Spectral analysis was performed in low- (LF: 0.04–0.15 Hz) and high-frequency bands (HF: 0.15–0.5 Hz). For coherences above 0.5, we calculated the LF transfer function between systolic BP and RRI, and the HF transfer function gain and phase between RRI and respiration. Differences between the on and off phases were evaluated using Wilcoxon test. Results – VNS did not change RRI and BP values. The LF power of BP and the LF and HF power of RRI increased significantly. There was a slight change in the RRI/BP LF gain and the RRI/respiration HF gain (ns). The HF phase between RRI and respiration decreased significantly. Conclusions – Our findings show that VNS influences both sympathetic and parasympathetic cardiovascular modulation. However, our results also show that VNS does not negatively influence autonomic cardiovascular regulation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1600-0404.2007.00944.x
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      – Code: eng
        Text: English
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        StartPage: 231
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      – SubjectFull: Neural stimulation
        Type: general
      – SubjectFull: People with epilepsy
        Type: general
      – SubjectFull: Heart rate monitoring
        Type: general
      – SubjectFull: Respiration
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      – SubjectFull: Chronically ill
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              Text: Apr2008
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              Y: 2008
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