Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory.
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| Title: | Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory. |
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| Authors: | Sue-Hyun Lee, Jun-Hyeok Choi, Lee, Nuribalhae, Hye-Ryeon Lee, Jae-Ick Kim, Nam-Kyung Yu, Sun-Lim Choi, Seung-Hee Lee, Hyoung Kim, Bong-Kiun Kaang |
| Source: | Science (pre-March 2025). 2/29/2008, Vol. 319 Issue 5867, p1253-1256. 4p. 3 Graphs. |
| Subjects: | Protein synthesis, Protein deficiency, Recovered memory, Fear, Thought & thinking, Neural transmission, Ubiquitin, Neurotransmitters, Hippocampus (Brain) |
| Abstract: | Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved in the reorganization of retrieved memory. We found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after retrieval of contextual fear memory. Moreover, the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin-induced memory impairment, as well as the extinction of fear memory. This suggests that ubiquitin- and proteasome-dependent protein degradation underlies destabilization processes after fear memory retrieval. It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 31220389 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sue-Hyun+Lee%22">Sue-Hyun Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Jun-Hyeok+Choi%22">Jun-Hyeok Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Nuribalhae%22">Lee, Nuribalhae</searchLink><br /><searchLink fieldCode="AR" term="%22Hye-Ryeon+Lee%22">Hye-Ryeon Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Jae-Ick+Kim%22">Jae-Ick Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Nam-Kyung+Yu%22">Nam-Kyung Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Sun-Lim+Choi%22">Sun-Lim Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Seung-Hee+Lee%22">Seung-Hee Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Hyoung+Kim%22">Hyoung Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Bong-Kiun+Kaang%22">Bong-Kiun Kaang</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/29/2008, Vol. 319 Issue 5867, p1253-1256. 4p. 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Protein+synthesis%22">Protein synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+deficiency%22">Protein deficiency</searchLink><br /><searchLink fieldCode="DE" term="%22Recovered+memory%22">Recovered memory</searchLink><br /><searchLink fieldCode="DE" term="%22Fear%22">Fear</searchLink><br /><searchLink fieldCode="DE" term="%22Thought+%26+thinking%22">Thought & thinking</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Ubiquitin%22">Ubiquitin</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved in the reorganization of retrieved memory. We found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after retrieval of contextual fear memory. Moreover, the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin-induced memory impairment, as well as the extinction of fear memory. This suggests that ubiquitin- and proteasome-dependent protein degradation underlies destabilization processes after fear memory retrieval. It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=31220389 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1150541 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1253 Subjects: – SubjectFull: Protein synthesis Type: general – SubjectFull: Protein deficiency Type: general – SubjectFull: Recovered memory Type: general – SubjectFull: Fear Type: general – SubjectFull: Thought & thinking Type: general – SubjectFull: Neural transmission Type: general – SubjectFull: Ubiquitin Type: general – SubjectFull: Neurotransmitters Type: general – SubjectFull: Hippocampus (Brain) Type: general Titles: – TitleFull: Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sue-Hyun Lee – PersonEntity: Name: NameFull: Jun-Hyeok Choi – PersonEntity: Name: NameFull: Lee, Nuribalhae – PersonEntity: Name: NameFull: Hye-Ryeon Lee – PersonEntity: Name: NameFull: Jae-Ick Kim – PersonEntity: Name: NameFull: Nam-Kyung Yu – PersonEntity: Name: NameFull: Sun-Lim Choi – PersonEntity: Name: NameFull: Seung-Hee Lee – PersonEntity: Name: NameFull: Hyoung Kim – PersonEntity: Name: NameFull: Bong-Kiun Kaang IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 02 Text: 2/29/2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 319 – Type: issue Value: 5867 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
