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Sensitization of meningeal nociceptors: inhibition by naproxen.

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Title: Sensitization of meningeal nociceptors: inhibition by naproxen.
Authors: Levy, Dan (AUTHOR), Zhang, Xi‐Chun (AUTHOR), Jakubowski, Moshe (AUTHOR), Burstein, Rami (AUTHOR)
Source: European Journal of Neuroscience. Feb2008, Vol. 27 Issue 4, p917-922. 6p. 5 Graphs.
Subjects: Nociceptors, Naproxen, Migraine, Cyclooxygenase 2 inhibitors, Neurons, Allodynia
Abstract: Migraine attacks associated with throbbing (manifestation of peripheral sensitization) and cutaneous allodynia (manifestation of central sensitization) are readily terminated by intravenous administration of a non-selective cyclooxygenase (COX) inhibitor. Evidence that sensitization of rat central trigeminovascular neurons was also terminated in vivo by non-selective COX inhibition has led us to propose that COX inhibitors may act centrally in the dorsal horn. In the present study, we examined whether COX inhibition can also suppress peripheral sensitization in meningeal nociceptors. Using single-unit recording in the trigeminal ganglion in vivo, we found that intravenous infusion of naproxen, a non-selective COX inhibitor, reversed measures of sensitization induced in meningeal nociceptors by prior exposure of the dura to inflammatory soup (IS): ongoing activity of Aδ- and C-units and their response magnitude to mechanical stimulation of the dura, which were enhanced after IS, returned to baseline after naproxen infusion. Topical application of naproxen or the selective COX-2 inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398) onto the dural receptive field of Aδ- and C-unit nociceptors also reversed the neuronal hyper-responsiveness to mechanical stimulation of the dura. The findings suggest that local COX activity in the dura could mediate the peripheral sensitization that underlies migraine headache. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sensitization of meningeal nociceptors: inhibition by naproxen.
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Levy%2C+Dan%22">Levy, Dan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xi‐Chun%22">Zhang, Xi‐Chun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jakubowski%2C+Moshe%22">Jakubowski, Moshe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burstein%2C+Rami%22">Burstein, Rami</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Feb2008, Vol. 27 Issue 4, p917-922. 6p. 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Nociceptors%22">Nociceptors</searchLink><br /><searchLink fieldCode="DE" term="%22Naproxen%22">Naproxen</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclooxygenase+2+inhibitors%22">Cyclooxygenase 2 inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Allodynia%22">Allodynia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Migraine attacks associated with throbbing (manifestation of peripheral sensitization) and cutaneous allodynia (manifestation of central sensitization) are readily terminated by intravenous administration of a non-selective cyclooxygenase (COX) inhibitor. Evidence that sensitization of rat central trigeminovascular neurons was also terminated in vivo by non-selective COX inhibition has led us to propose that COX inhibitors may act centrally in the dorsal horn. In the present study, we examined whether COX inhibition can also suppress peripheral sensitization in meningeal nociceptors. Using single-unit recording in the trigeminal ganglion in vivo, we found that intravenous infusion of naproxen, a non-selective COX inhibitor, reversed measures of sensitization induced in meningeal nociceptors by prior exposure of the dura to inflammatory soup (IS): ongoing activity of Aδ- and C-units and their response magnitude to mechanical stimulation of the dura, which were enhanced after IS, returned to baseline after naproxen infusion. Topical application of naproxen or the selective COX-2 inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398) onto the dural receptive field of Aδ- and C-unit nociceptors also reversed the neuronal hyper-responsiveness to mechanical stimulation of the dura. The findings suggest that local COX activity in the dura could mediate the peripheral sensitization that underlies migraine headache. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1111/j.1460-9568.2008.06068.x
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      – Code: eng
        Text: English
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      – SubjectFull: Naproxen
        Type: general
      – SubjectFull: Migraine
        Type: general
      – SubjectFull: Cyclooxygenase 2 inhibitors
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      – SubjectFull: Neurons
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            NameFull: Zhang, Xi‐Chun
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            NameFull: Jakubowski, Moshe
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              Text: Feb2008
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              Y: 2008
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