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α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

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Title: α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking.
Authors: Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., Waterworth, D., Muglia, P., Mooser, V.
Source: Molecular Psychiatry. Apr2008, Vol. 13 Issue 4, p368-373. 6p. 2 Diagrams, 2 Charts.
Subjects: Nicotinic receptors, Smoking, Genetics, Nicotine addiction, Cigarettes, Europeans
Abstract: Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these ∼7500 persons, a common haplotype in the CHRNA3–CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 × 10−5). In a third set of European populations (n=∼7500) which had been genotyped for ∼6000 SNPs in ∼2000 genes, an allele in the same haplotype was associated with CPD (nominal P=2.6 × 10−6). These results (in three independent populations of European origin, totaling ∼15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND.Molecular Psychiatry (2008) 13, 368–373; doi:10.1038/sj.mp.4002154; published online 29 January 2008 [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking.
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  Data: <searchLink fieldCode="AR" term="%22Berrettini%2C+W%2E%22">Berrettini, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+X%2E%22">Yuan, X.</searchLink><br /><searchLink fieldCode="AR" term="%22Tozzi%2C+F%2E%22">Tozzi, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+K%2E%22">Song, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Francks%2C+C%2E%22">Francks, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Chilcoat%2C+H%2E%22">Chilcoat, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Waterworth%2C+D%2E%22">Waterworth, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Muglia%2C+P%2E%22">Muglia, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Mooser%2C+V%2E%22">Mooser, V.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2008, Vol. 13 Issue 4, p368-373. 6p. 2 Diagrams, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Nicotinic+receptors%22">Nicotinic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotine+addiction%22">Nicotine addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Cigarettes%22">Cigarettes</searchLink><br /><searchLink fieldCode="DE" term="%22Europeans%22">Europeans</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these ∼7500 persons, a common haplotype in the CHRNA3–CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 × 10−5). In a third set of European populations (n=∼7500) which had been genotyped for ∼6000 SNPs in ∼2000 genes, an allele in the same haplotype was associated with CPD (nominal P=2.6 × 10−6). These results (in three independent populations of European origin, totaling ∼15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND.Molecular Psychiatry (2008) 13, 368–373; doi:10.1038/sj.mp.4002154; published online 29 January 2008 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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