A collaborative knowledge base for cognitive phenomics.
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| Title: | A collaborative knowledge base for cognitive phenomics. |
|---|---|
| Authors: | Sabb, F. W., Bearden, C. E., Glahn, D. C., Parker, D. S., Freimer, N., Bilder, R. M. |
| Source: | Molecular Psychiatry. Apr2008, Vol. 13 Issue 4, p350-360. 11p. 3 Diagrams, 4 Charts, 1 Graph. |
| Subjects: | Genomes, Phenotypes, Neuropsychiatry, Psychiatric research, Information science |
| Abstract: | The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a ‘bottom-up’ fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representation and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to ‘cognitive control’, a neurocognitive construct considered important to multiple neuropsychiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n=449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.Molecular Psychiatry (2008) 13, 350–360; doi:10.1038/sj.mp.4002124; published online 8 January 2008 [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 31314707 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A collaborative knowledge base for cognitive phenomics. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sabb%2C+F%2E+W%2E%22">Sabb, F. W.</searchLink><br /><searchLink fieldCode="AR" term="%22Bearden%2C+C%2E+E%2E%22">Bearden, C. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Glahn%2C+D%2E+C%2E%22">Glahn, D. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Parker%2C+D%2E+S%2E%22">Parker, D. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Freimer%2C+N%2E%22">Freimer, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Bilder%2C+R%2E+M%2E%22">Bilder, R. M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2008, Vol. 13 Issue 4, p350-360. 11p. 3 Diagrams, 4 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychiatry%22">Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+research%22">Psychiatric research</searchLink><br /><searchLink fieldCode="DE" term="%22Information+science%22">Information science</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a ‘bottom-up’ fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representation and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to ‘cognitive control’, a neurocognitive construct considered important to multiple neuropsychiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n=449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.Molecular Psychiatry (2008) 13, 350–360; doi:10.1038/sj.mp.4002124; published online 8 January 2008 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=31314707 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4002124 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 350 Subjects: – SubjectFull: Genomes Type: general – SubjectFull: Phenotypes Type: general – SubjectFull: Neuropsychiatry Type: general – SubjectFull: Psychiatric research Type: general – SubjectFull: Information science Type: general Titles: – TitleFull: A collaborative knowledge base for cognitive phenomics. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sabb, F. W. – PersonEntity: Name: NameFull: Bearden, C. E. – PersonEntity: Name: NameFull: Glahn, D. C. – PersonEntity: Name: NameFull: Parker, D. S. – PersonEntity: Name: NameFull: Freimer, N. – PersonEntity: Name: NameFull: Bilder, R. M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 13 – Type: issue Value: 4 Titles: – TitleFull: Molecular Psychiatry Type: main |
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