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Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.

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Title: Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.
Authors: Kuratomi, G., Iwamoto, K., Bundo, M., Kusumi, I., Kato, N., Iwata, N., Ozaki, N., Kato, T.
Source: Molecular Psychiatry. Apr2008, Vol. 13 Issue 4, p429-441. 13p. 2 Diagrams, 2 Charts, 3 Graphs.
Subjects: DNA, Methylation, Bipolar disorder, Twins, Lymphoblastoid cell lines, Gene expression
Abstract: To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA) to lymphoblastoid cells derived from the twins. MS-RDA isolated 10 DNA fragments derived from 5′ region of known genes/ESTs. Among these 10 regions, four regions showed DNA methylation differences between bipolar twin and control co-twin confirmed by bisulfite sequencing. We performed a case–control study of DNA methylation status of these four regions by pyrosequencing. Two regions, upstream regions of spermine synthase (SMS) and peptidylprolyl isomerase E-like (PPIEL) (CN265253), showed aberrant DNA methylation status in bipolar disorder. SMS, a gene on X chromosome, showed significantly higher DNA methylation level in female patients with bipolar disorder compared with control females. However, there was no difference of mRNA expression. In PPIEL, DNA methylation level was significantly lower in patients with bipolar II disorder than in controls. The expression level of PPIEL was significantly higher in bipolar II disorder than in controls. We found strong inverse correlation between gene expression and DNA methylation levels of PPIEL. These results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder.Molecular Psychiatry (2008) 13, 429–441; doi:10.1038/sj.mp.4002001; published online 1 May 2007 [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.
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  Data: <searchLink fieldCode="AR" term="%22Kuratomi%2C+G%2E%22">Kuratomi, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Iwamoto%2C+K%2E%22">Iwamoto, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Bundo%2C+M%2E%22">Bundo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kusumi%2C+I%2E%22">Kusumi, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Kato%2C+N%2E%22">Kato, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Iwata%2C+N%2E%22">Iwata, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Ozaki%2C+N%2E%22">Ozaki, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Kato%2C+T%2E%22">Kato, T.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2008, Vol. 13 Issue 4, p429-441. 13p. 2 Diagrams, 2 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Methylation%22">Methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Twins%22">Twins</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphoblastoid+cell+lines%22">Lymphoblastoid cell lines</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
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  Data: To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA) to lymphoblastoid cells derived from the twins. MS-RDA isolated 10 DNA fragments derived from 5′ region of known genes/ESTs. Among these 10 regions, four regions showed DNA methylation differences between bipolar twin and control co-twin confirmed by bisulfite sequencing. We performed a case–control study of DNA methylation status of these four regions by pyrosequencing. Two regions, upstream regions of spermine synthase (SMS) and peptidylprolyl isomerase E-like (PPIEL) (CN265253), showed aberrant DNA methylation status in bipolar disorder. SMS, a gene on X chromosome, showed significantly higher DNA methylation level in female patients with bipolar disorder compared with control females. However, there was no difference of mRNA expression. In PPIEL, DNA methylation level was significantly lower in patients with bipolar II disorder than in controls. The expression level of PPIEL was significantly higher in bipolar II disorder than in controls. We found strong inverse correlation between gene expression and DNA methylation levels of PPIEL. These results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder.Molecular Psychiatry (2008) 13, 429–441; doi:10.1038/sj.mp.4002001; published online 1 May 2007 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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