Thyrotrophin in the pars tuberalis triggers photoperiodic response.

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Bibliographic Details
Title:	Thyrotrophin in the pars tuberalis triggers photoperiodic response.
Authors:	Nakao, Nobuhiro, Ono, Hiroko, Yamamura, Takashi, Anraku, Tsubasa, Takagi, Tsuyoshi, Higashi, Kumiko, Yasuo, Shinobu, Katou, Yasuhiro, Kageyama, Saburo, Uno, Yumiko, Kasukawa, Takeya, Iigo, Masayuki, Sharp, Peter J., Iwasawa, Atsushi, Suzuki, Yutaka, Sugano, Sumio, Niimi, Teruyuki, Mizutani, Makoto, Namikawa, Takao, Ebihara, Shizufumi
Source:	Nature. 3/20/2008, Vol. 452 Issue 7185, p317-322. 6p. 5 Graphs.
Subjects:	Hypothalamus, Japanese quail, Animal breeding, Thyroid hormones, Gene expression, Pituitary hormones, Endocrine glands, Genetic regulation, Thyrotropin, Cyclic adenylic acid
Abstract:	Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) β-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor–cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) β-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor–cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding. [ABSTRACT FROM AUTHOR]
ISSN:	00280836
DOI:	10.1038/nature06738