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The contribution of pharmacoepidemiology to the antidepressant-suicidality debate in children and adolescents.

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Title: The contribution of pharmacoepidemiology to the antidepressant-suicidality debate in children and adolescents.
Authors: Bridge, Jeffrey A. (AUTHOR), Axelson, David A. (AUTHOR)
Source: International Review of Psychiatry. Apr2008, Vol. 20 Issue 2, p209-214. 6p. 1 Chart.
Subjects: Antidepressants, Pharmacoepidemiology, Suicidal behavior, Teenagers, Psychiatric drugs
Abstract: A number of concerns have recently been raised about whether or not antidepressant medications are associated with suicidal thoughts and behaviour in children and adolescents. These concerns are based largely on results of meta-analyses of randomized, controlled trials (RCTs). Controversy exists about generalizing evidence from short-term RCTs, designed primarily to test efficacy outcomes, to routine practice settings. Pharmacoepidemiological studies complement RCTs by using observational methods to examine safety and effectiveness of medications in the general population. This article reviews the contribution of pharmacoepidemiology to the controversy surrounding suicide risk in children and adolescents taking antidepressants, noting how variations in study design and adjustment for potential confounding factors influence outcome. [ABSTRACT FROM AUTHOR]
Copyright of International Review of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The contribution of pharmacoepidemiology to the antidepressant-suicidality debate in children and adolescents.
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  Data: <searchLink fieldCode="AR" term="%22Bridge%2C+Jeffrey+A%2E%22">Bridge, Jeffrey A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Axelson%2C+David+A%2E%22">Axelson, David A.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Review+of+Psychiatry%22">International Review of Psychiatry</searchLink>. Apr2008, Vol. 20 Issue 2, p209-214. 6p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacoepidemiology%22">Pharmacoepidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Suicidal+behavior%22">Suicidal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Teenagers%22">Teenagers</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink>
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  Data: A number of concerns have recently been raised about whether or not antidepressant medications are associated with suicidal thoughts and behaviour in children and adolescents. These concerns are based largely on results of meta-analyses of randomized, controlled trials (RCTs). Controversy exists about generalizing evidence from short-term RCTs, designed primarily to test efficacy outcomes, to routine practice settings. Pharmacoepidemiological studies complement RCTs by using observational methods to examine safety and effectiveness of medications in the general population. This article reviews the contribution of pharmacoepidemiology to the controversy surrounding suicide risk in children and adolescents taking antidepressants, noting how variations in study design and adjustment for potential confounding factors influence outcome. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Review of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09540260801889245
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        Text: English
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      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Pharmacoepidemiology
        Type: general
      – SubjectFull: Suicidal behavior
        Type: general
      – SubjectFull: Teenagers
        Type: general
      – SubjectFull: Psychiatric drugs
        Type: general
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      – TitleFull: The contribution of pharmacoepidemiology to the antidepressant-suicidality debate in children and adolescents.
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              Text: Apr2008
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              Y: 2008
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