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Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia.

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Title: Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia.
Authors: Fang, Carolyn Y., Miller, Suzanne M., Bovbjerg, Dana H., Bergman, Cynthia, Edelson, Mitchell I., Rosenblum, Norman G., Bove, Betsy A., Godwin, Andrew K., Campbell, Donald E., Douglas, Steven D.
Source: Annals of Behavioral Medicine. 2008, Vol. 35 Issue 1, p87-96. 10p. 3 Charts.
Subjects: Papillomaviruses, Diseases in women, Cellular immunity, Cervix uteri diseases, Dysplasia, T cells
Abstract: Infection with high-risk subtypes of human papillomavirus (HPV) is a central factor in the development of cervical neoplasia. Cell-mediated immunity against HPV16 plays an important role in the resolution of HPV infection and in controlling cervical disease progression. Research suggests that stress is associated with cervical disease progression, but few studies have examined the biological mechanisms that may be driving this association. This study examines whether stress is associated with immune response to HPV16 among women with cervical dysplasia. Seventy-four women presenting for colposcopy completed measures of health behaviors, stressful life events and perceived stress. A blood sample was obtained to evaluate proliferative T-cell response to HPV16, and a cervical sample was obtained during gynecologic exam for HPV-typing. More than 55% tested positive for one or more HPV subtypes. Women who did not show proliferative responses to HPV (i.e. non-responders) were more likely to be HPV+ compared to women who had a response (i.e. responders). Consistent with study hypotheses, logistic regression revealed that higher levels of perceived stress were associated with a non-response to HPV16, controlling for relevant covariates. Stressful life events were not associated with T-cell response to HPV. Higher levels of perceived stress are associated with impaired HPV-specific immune response in women with cervical dysplasia, suggesting a potential mechanism by which stress may influence cervical disease progression. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Behavioral Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia.
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  Data: <searchLink fieldCode="AR" term="%22Fang%2C+Carolyn+Y%2E%22">Fang, Carolyn Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+Suzanne+M%2E%22">Miller, Suzanne M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bovbjerg%2C+Dana+H%2E%22">Bovbjerg, Dana H.</searchLink><br /><searchLink fieldCode="AR" term="%22Bergman%2C+Cynthia%22">Bergman, Cynthia</searchLink><br /><searchLink fieldCode="AR" term="%22Edelson%2C+Mitchell+I%2E%22">Edelson, Mitchell I.</searchLink><br /><searchLink fieldCode="AR" term="%22Rosenblum%2C+Norman+G%2E%22">Rosenblum, Norman G.</searchLink><br /><searchLink fieldCode="AR" term="%22Bove%2C+Betsy+A%2E%22">Bove, Betsy A.</searchLink><br /><searchLink fieldCode="AR" term="%22Godwin%2C+Andrew+K%2E%22">Godwin, Andrew K.</searchLink><br /><searchLink fieldCode="AR" term="%22Campbell%2C+Donald+E%2E%22">Campbell, Donald E.</searchLink><br /><searchLink fieldCode="AR" term="%22Douglas%2C+Steven+D%2E%22">Douglas, Steven D.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Behavioral+Medicine%22">Annals of Behavioral Medicine</searchLink>. 2008, Vol. 35 Issue 1, p87-96. 10p. 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Papillomaviruses%22">Papillomaviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+in+women%22">Diseases in women</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+immunity%22">Cellular immunity</searchLink><br /><searchLink fieldCode="DE" term="%22Cervix+uteri+diseases%22">Cervix uteri diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Dysplasia%22">Dysplasia</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink>
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  Data: Infection with high-risk subtypes of human papillomavirus (HPV) is a central factor in the development of cervical neoplasia. Cell-mediated immunity against HPV16 plays an important role in the resolution of HPV infection and in controlling cervical disease progression. Research suggests that stress is associated with cervical disease progression, but few studies have examined the biological mechanisms that may be driving this association. This study examines whether stress is associated with immune response to HPV16 among women with cervical dysplasia. Seventy-four women presenting for colposcopy completed measures of health behaviors, stressful life events and perceived stress. A blood sample was obtained to evaluate proliferative T-cell response to HPV16, and a cervical sample was obtained during gynecologic exam for HPV-typing. More than 55% tested positive for one or more HPV subtypes. Women who did not show proliferative responses to HPV (i.e. non-responders) were more likely to be HPV+ compared to women who had a response (i.e. responders). Consistent with study hypotheses, logistic regression revealed that higher levels of perceived stress were associated with a non-response to HPV16, controlling for relevant covariates. Stressful life events were not associated with T-cell response to HPV. Higher levels of perceived stress are associated with impaired HPV-specific immune response in women with cervical dysplasia, suggesting a potential mechanism by which stress may influence cervical disease progression. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Behavioral Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s12160-007-9007-6
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        Type: general
      – SubjectFull: Diseases in women
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      – SubjectFull: Cellular immunity
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      – TitleFull: Perceived Stress is Associated with Impaired T-Cell Response to HPV16 in Women with Cervical Dysplasia.
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