Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans.
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| Title: | Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans. |
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| Authors: | Kuhara, Atsushi, Okumura, Masatoshi, Kimata, Tsubasa, Tanizawa, Yoshinori, Takano, Ryo, Kimura, Koutarou D., Inada, Hitoshi, Matsumoto, Kunihiro, Mori, Ikue |
| Source: | Science (pre-March 2025). 5/9/2008, Vol. 320 Issue 5877, p803-807. 5p. 4 Graphs. |
| Subjects: | Nematodes, Calcium, Cranial nerves, Neurons, Nervous system, Axons, Dendrites, Senses, Physiological effects of temperature |
| Abstract: | Temperature is an unavoidable environmental cue that affects the metabolism and behavior of any creature on Earth, yet how animals perceive temperature is poorly understood. The nematode Coenorhabditis elegans "memorizes" temperatures, and this stored information modifies its subsequent migration along a temperature gradient. We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucleotide-binding protein (6 protein)-mediated signaling, AWC was hyperresponsive to temperature, whereas the AIY interneuron (which is postsynaptic to AWC) was hyporesponsive to temperature. Thus, temperature sensation exhibits a robust influence on a neural circuit controlling a memory-regulated behavior. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 32102836 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kuhara%2C+Atsushi%22">Kuhara, Atsushi</searchLink><br /><searchLink fieldCode="AR" term="%22Okumura%2C+Masatoshi%22">Okumura, Masatoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Kimata%2C+Tsubasa%22">Kimata, Tsubasa</searchLink><br /><searchLink fieldCode="AR" term="%22Tanizawa%2C+Yoshinori%22">Tanizawa, Yoshinori</searchLink><br /><searchLink fieldCode="AR" term="%22Takano%2C+Ryo%22">Takano, Ryo</searchLink><br /><searchLink fieldCode="AR" term="%22Kimura%2C+Koutarou+D%2E%22">Kimura, Koutarou D.</searchLink><br /><searchLink fieldCode="AR" term="%22Inada%2C+Hitoshi%22">Inada, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Matsumoto%2C+Kunihiro%22">Matsumoto, Kunihiro</searchLink><br /><searchLink fieldCode="AR" term="%22Mori%2C+Ikue%22">Mori, Ikue</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 5/9/2008, Vol. 320 Issue 5877, p803-807. 5p. 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nematodes%22">Nematodes</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium%22">Calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Cranial+nerves%22">Cranial nerves</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Axons%22">Axons</searchLink><br /><searchLink fieldCode="DE" term="%22Dendrites%22">Dendrites</searchLink><br /><searchLink fieldCode="DE" term="%22Senses%22">Senses</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+temperature%22">Physiological effects of temperature</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Temperature is an unavoidable environmental cue that affects the metabolism and behavior of any creature on Earth, yet how animals perceive temperature is poorly understood. The nematode Coenorhabditis elegans "memorizes" temperatures, and this stored information modifies its subsequent migration along a temperature gradient. We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucleotide-binding protein (6 protein)-mediated signaling, AWC was hyperresponsive to temperature, whereas the AIY interneuron (which is postsynaptic to AWC) was hyporesponsive to temperature. Thus, temperature sensation exhibits a robust influence on a neural circuit controlling a memory-regulated behavior. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=32102836 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1148922 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 803 Subjects: – SubjectFull: Nematodes Type: general – SubjectFull: Calcium Type: general – SubjectFull: Cranial nerves Type: general – SubjectFull: Neurons Type: general – SubjectFull: Nervous system Type: general – SubjectFull: Axons Type: general – SubjectFull: Dendrites Type: general – SubjectFull: Senses Type: general – SubjectFull: Physiological effects of temperature Type: general Titles: – TitleFull: Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kuhara, Atsushi – PersonEntity: Name: NameFull: Okumura, Masatoshi – PersonEntity: Name: NameFull: Kimata, Tsubasa – PersonEntity: Name: NameFull: Tanizawa, Yoshinori – PersonEntity: Name: NameFull: Takano, Ryo – PersonEntity: Name: NameFull: Kimura, Koutarou D. – PersonEntity: Name: NameFull: Inada, Hitoshi – PersonEntity: Name: NameFull: Matsumoto, Kunihiro – PersonEntity: Name: NameFull: Mori, Ikue IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 05 Text: 5/9/2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 320 – Type: issue Value: 5877 Titles: – TitleFull: Science (pre-March 2025) Type: main |
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