Comparison of 50- and 100-g l-tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states.
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| Title: | Comparison of 50- and 100-g l-tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states. |
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| Authors: | Dougherty, Donald, Marsh-Richard, Dawn, Mathias, Charles, Hood, Ashley, Addicott, Merideth, Moeller, F., Morgan, Christopher, Badawy, Abdulla |
| Source: | Psychopharmacology. Jun2008, Vol. 198 Issue 3, p431-445. 15p. 3 Charts, 2 Graphs. |
| Subjects: | Serotonin, Drug side effects, Mood (Psychology), Tryptophan, Physiology |
| Abstract: | Differences in 5-hydroxytryptamine (5-HT) function have been the subject of extensive research in psychiatric studies. Many studies have manipulated l-tryptophan (Trp) levels to temporarily decrease (depletion) or increase (loading) 5-HT synthesis. While most researchers have used a 100-g formulation, there has been ongoing interest in using smaller-sized formulations. This study examined the time course of multiple plasma indicators of brain 5-HT synthesis after a 50-g depletion and loading as a comparison to the corresponding 100-g formulations that are typically used. Plasma was collected from 112 healthy adults at seven hourly intervals after consumption of either a 50- or 100-g depletion or loading. Self-ratings of mood and somatic symptoms were completed before and after Trp manipulations. The primary findings were that (1) the 50- and 100-g formulations produced the expected changes in plasma indicators after both depletion (−89% and −96%, respectively) and loading (+570% and +372%, respectively); (2) the 100-g depletion showed more robust effects at the 4, 5, and 6 h measurements than the 50-g depletion; (3) there was significant attrition after both the 100-g depletion and loading, but not after either of the 50-g formulations; and (4) both the 50- and 100-g depletions produced increases in negative self-ratings of mood and somatic symptoms, while loading significantly increased negative ratings after the 100 g only. There are important considerations when choosing among formulation sizes for use in Trp manipulation studies, and the complete 7-h time-course data set of the typical plasma Trp measures presented here may help researchers decide which methodology best suits their needs. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 32118805 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of 50- and 100-g l-tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dougherty%2C+Donald%22">Dougherty, Donald</searchLink><br /><searchLink fieldCode="AR" term="%22Marsh-Richard%2C+Dawn%22">Marsh-Richard, Dawn</searchLink><br /><searchLink fieldCode="AR" term="%22Mathias%2C+Charles%22">Mathias, Charles</searchLink><br /><searchLink fieldCode="AR" term="%22Hood%2C+Ashley%22">Hood, Ashley</searchLink><br /><searchLink fieldCode="AR" term="%22Addicott%2C+Merideth%22">Addicott, Merideth</searchLink><br /><searchLink fieldCode="AR" term="%22Moeller%2C+F%2E%22">Moeller, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Morgan%2C+Christopher%22">Morgan, Christopher</searchLink><br /><searchLink fieldCode="AR" term="%22Badawy%2C+Abdulla%22">Badawy, Abdulla</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jun2008, Vol. 198 Issue 3, p431-445. 15p. 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Mood+%28Psychology%29%22">Mood (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Tryptophan%22">Tryptophan</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Differences in 5-hydroxytryptamine (5-HT) function have been the subject of extensive research in psychiatric studies. Many studies have manipulated l-tryptophan (Trp) levels to temporarily decrease (depletion) or increase (loading) 5-HT synthesis. While most researchers have used a 100-g formulation, there has been ongoing interest in using smaller-sized formulations. This study examined the time course of multiple plasma indicators of brain 5-HT synthesis after a 50-g depletion and loading as a comparison to the corresponding 100-g formulations that are typically used. Plasma was collected from 112 healthy adults at seven hourly intervals after consumption of either a 50- or 100-g depletion or loading. Self-ratings of mood and somatic symptoms were completed before and after Trp manipulations. The primary findings were that (1) the 50- and 100-g formulations produced the expected changes in plasma indicators after both depletion (−89% and −96%, respectively) and loading (+570% and +372%, respectively); (2) the 100-g depletion showed more robust effects at the 4, 5, and 6 h measurements than the 50-g depletion; (3) there was significant attrition after both the 100-g depletion and loading, but not after either of the 50-g formulations; and (4) both the 50- and 100-g depletions produced increases in negative self-ratings of mood and somatic symptoms, while loading significantly increased negative ratings after the 100 g only. There are important considerations when choosing among formulation sizes for use in Trp manipulation studies, and the complete 7-h time-course data set of the typical plasma Trp measures presented here may help researchers decide which methodology best suits their needs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-008-1163-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 431 Subjects: – SubjectFull: Serotonin Type: general – SubjectFull: Drug side effects Type: general – SubjectFull: Mood (Psychology) Type: general – SubjectFull: Tryptophan Type: general – SubjectFull: Physiology Type: general Titles: – TitleFull: Comparison of 50- and 100-g l-tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dougherty, Donald – PersonEntity: Name: NameFull: Marsh-Richard, Dawn – PersonEntity: Name: NameFull: Mathias, Charles – PersonEntity: Name: NameFull: Hood, Ashley – PersonEntity: Name: NameFull: Addicott, Merideth – PersonEntity: Name: NameFull: Moeller, F. – PersonEntity: Name: NameFull: Morgan, Christopher – PersonEntity: Name: NameFull: Badawy, Abdulla IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 198 – Type: issue Value: 3 Titles: – TitleFull: Psychopharmacology Type: main |
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