Micro-engineered local field control for high-sensitivity multispectral MRI.
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| Title: | Micro-engineered local field control for high-sensitivity multispectral MRI. |
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| Authors: | Zabow, Gary, Dodd, Stephen, Moreland, John, Koretsky, Alan |
| Source: | Nature. 6/19/2008, Vol. 453 Issue 7198, p1058-1063. 6p. 1 Black and White Photograph, 2 Diagrams, 2 Graphs. |
| Subjects: | Magnetic resonance imaging, Microfabrication, Microstructure, Magnetics, Radio frequency, Quantum dots |
| Abstract: | In recent years, biotechnology and biomedical research have benefited from the introduction of a variety of specialized nanoparticles whose well-defined, optically distinguishable signatures enable simultaneous tracking of numerous biological indicators. Unfortunately, equivalent multiplexing capabilities are largely absent in the field of magnetic resonance imaging (MRI). Comparable magnetic-resonance labels have generally been limited to relatively simple chemically synthesized superparamagnetic microparticles that are, to a large extent, indistinguishable from one another. Here we show how it is instead possible to use a top-down microfabrication approach to effectively encode distinguishable spectral signatures into the geometry of magnetic microstructures. Although based on different physical principles from those of optically probed nanoparticles, these geometrically defined magnetic microstructures permit a multiplexing functionality in the magnetic resonance radio-frequency spectrum that is in many ways analogous to that permitted by quantum dots in the optical spectrum. Additionally, in situ modification of particle geometries may facilitate radio-frequency probing of various local physiological variables. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 32661633 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Micro-engineered local field control for high-sensitivity multispectral MRI. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zabow%2C+Gary%22">Zabow, Gary</searchLink><br /><searchLink fieldCode="AR" term="%22Dodd%2C+Stephen%22">Dodd, Stephen</searchLink><br /><searchLink fieldCode="AR" term="%22Moreland%2C+John%22">Moreland, John</searchLink><br /><searchLink fieldCode="AR" term="%22Koretsky%2C+Alan%22">Koretsky, Alan</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 6/19/2008, Vol. 453 Issue 7198, p1058-1063. 6p. 1 Black and White Photograph, 2 Diagrams, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Microfabrication%22">Microfabrication</searchLink><br /><searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetics%22">Magnetics</searchLink><br /><searchLink fieldCode="DE" term="%22Radio+frequency%22">Radio frequency</searchLink><br /><searchLink fieldCode="DE" term="%22Quantum+dots%22">Quantum dots</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In recent years, biotechnology and biomedical research have benefited from the introduction of a variety of specialized nanoparticles whose well-defined, optically distinguishable signatures enable simultaneous tracking of numerous biological indicators. Unfortunately, equivalent multiplexing capabilities are largely absent in the field of magnetic resonance imaging (MRI). Comparable magnetic-resonance labels have generally been limited to relatively simple chemically synthesized superparamagnetic microparticles that are, to a large extent, indistinguishable from one another. Here we show how it is instead possible to use a top-down microfabrication approach to effectively encode distinguishable spectral signatures into the geometry of magnetic microstructures. Although based on different physical principles from those of optically probed nanoparticles, these geometrically defined magnetic microstructures permit a multiplexing functionality in the magnetic resonance radio-frequency spectrum that is in many ways analogous to that permitted by quantum dots in the optical spectrum. Additionally, in situ modification of particle geometries may facilitate radio-frequency probing of various local physiological variables. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature07048 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1058 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Microfabrication Type: general – SubjectFull: Microstructure Type: general – SubjectFull: Magnetics Type: general – SubjectFull: Radio frequency Type: general – SubjectFull: Quantum dots Type: general Titles: – TitleFull: Micro-engineered local field control for high-sensitivity multispectral MRI. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zabow, Gary – PersonEntity: Name: NameFull: Dodd, Stephen – PersonEntity: Name: NameFull: Moreland, John – PersonEntity: Name: NameFull: Koretsky, Alan IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 06 Text: 6/19/2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 453 – Type: issue Value: 7198 Titles: – TitleFull: Nature Type: main |
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