View in EDS HTML Full Text PDF Full Text

Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route.

Saved in:
Bibliographic Details
Title: Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route.
Authors: Praetorius, Mark (AUTHOR), Vicario, Ignacio (AUTHOR), Schimmang, >Thomas (AUTHOR)
Source: Acta Oto-Laryngologica. Jul2008, Vol. 128 Issue 7, p720-723. 4p. 1 Black and White Photograph, 2 Diagrams.
Subjects: Cell transplantation, Cochlea, Embryonic stem cells, Vestibular apparatus, Inner ear
Abstract: Conclusion. Cell transplantation into the utriculus provides an efficient and non-invasive route to introduce embryonic stem (ES) cells into the vestibular and cochlear portions of the inner ear. Objective. The transfer of stem cells into the inner ear for therapeutic purposes is an important approach to cure damage to the cochlea and vestibulum. A key issue is to provide an entry point for cell transplants into the inner ear that does not affect its physiologic functions. The aim of this study was to examine the feasibility of transferring ES cells into the inner ear via the utriculus. Materials and methods. ES cells were injected via utriculostomy into the mouse inner ear. The distribution of the injected cells was determined using a beta-galactosidase marker gene expressed by the ES cells. Results. Injected ES cells were found within the perilymph of the scala tympani and vestibuli. Moreover, ES cells were detected close to the cochlear sensory epithelium and spiral limbus. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 32706642
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Praetorius%2C+Mark%22">Praetorius, Mark</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vicario%2C+Ignacio%22">Vicario, Ignacio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schimmang%2C+>Thomas%22">Schimmang, >Thomas</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jul2008, Vol. 128 Issue 7, p720-723. 4p. 1 Black and White Photograph, 2 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cell+transplantation%22">Cell transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Cochlea%22">Cochlea</searchLink><br /><searchLink fieldCode="DE" term="%22Embryonic+stem+cells%22">Embryonic stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vestibular+apparatus%22">Vestibular apparatus</searchLink><br /><searchLink fieldCode="DE" term="%22Inner+ear%22">Inner ear</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusion. Cell transplantation into the utriculus provides an efficient and non-invasive route to introduce embryonic stem (ES) cells into the vestibular and cochlear portions of the inner ear. Objective. The transfer of stem cells into the inner ear for therapeutic purposes is an important approach to cure damage to the cochlea and vestibulum. A key issue is to provide an entry point for cell transplants into the inner ear that does not affect its physiologic functions. The aim of this study was to examine the feasibility of transferring ES cells into the inner ear via the utriculus. Materials and methods. ES cells were injected via utriculostomy into the mouse inner ear. The distribution of the injected cells was determined using a beta-galactosidase marker gene expressed by the ES cells. Results. Injected ES cells were found within the perilymph of the scala tympani and vestibuli. Moreover, ES cells were detected close to the cochlear sensory epithelium and spiral limbus. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=32706642
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016480701714236
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 720
    Subjects:
      – SubjectFull: Cell transplantation
        Type: general
      – SubjectFull: Cochlea
        Type: general
      – SubjectFull: Embryonic stem cells
        Type: general
      – SubjectFull: Vestibular apparatus
        Type: general
      – SubjectFull: Inner ear
        Type: general
    Titles:
      – TitleFull: Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Praetorius, Mark
      – PersonEntity:
          Name:
            NameFull: Vicario, Ignacio
      – PersonEntity:
          Name:
            NameFull: Schimmang, >Thomas
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2008
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 00016489
          Numbering:
            – Type: volume
              Value: 128
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Acta Oto-Laryngologica
              Type: main
ResultId 1