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Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone.

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Title: Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone.
Authors: Fishman, Marc (AUTHOR)
Source: Addiction. Aug2008, Vol. 103 Issue 8, p1399-1401. 3p.
Subjects: Opioid abuse, Naltrexone, Oxycodone, Narcotic antagonists, Codeine derivatives, Medication abuse
Abstract: Background There has been increasing interest in the use of extended release injectable naltrexone for the treatment of opioid dependence. Case description We report a case of precipitated withdrawal in a 17-year-old adolescent female receiving extended release naltrexone (Vivitrol) for opioid dependence, following her third serial monthly dose of the medication, several days after using oxycodone with mild intoxication. Conclusions This case suggests that, in some circumstances, the opioid blockade may be overcome when naltrexone levels drop towards the end of the dosing interval, producing vulnerability to subsequent naltrexone-induced withdrawal. This may provide cautionary guidance for clinical management and dosing strategies. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone.
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  Data: <searchLink fieldCode="AR" term="%22Fishman%2C+Marc%22">Fishman, Marc</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Aug2008, Vol. 103 Issue 8, p1399-1401. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Opioid+abuse%22">Opioid abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Naltrexone%22">Naltrexone</searchLink><br /><searchLink fieldCode="DE" term="%22Oxycodone%22">Oxycodone</searchLink><br /><searchLink fieldCode="DE" term="%22Narcotic+antagonists%22">Narcotic antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Codeine+derivatives%22">Codeine derivatives</searchLink><br /><searchLink fieldCode="DE" term="%22Medication+abuse%22">Medication abuse</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background There has been increasing interest in the use of extended release injectable naltrexone for the treatment of opioid dependence. Case description We report a case of precipitated withdrawal in a 17-year-old adolescent female receiving extended release naltrexone (Vivitrol) for opioid dependence, following her third serial monthly dose of the medication, several days after using oxycodone with mild intoxication. Conclusions This case suggests that, in some circumstances, the opioid blockade may be overcome when naltrexone levels drop towards the end of the dosing interval, producing vulnerability to subsequent naltrexone-induced withdrawal. This may provide cautionary guidance for clinical management and dosing strategies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1360-0443.2008.02252.x
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Opioid abuse
        Type: general
      – SubjectFull: Naltrexone
        Type: general
      – SubjectFull: Oxycodone
        Type: general
      – SubjectFull: Narcotic antagonists
        Type: general
      – SubjectFull: Codeine derivatives
        Type: general
      – SubjectFull: Medication abuse
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      – TitleFull: Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone.
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              Text: Aug2008
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