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High plasmatic angiotensin-converting enzyme (ACE) activity is not correlated with training-induced left ventricular growth in ACE congenic rats.

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Title: High plasmatic angiotensin-converting enzyme (ACE) activity is not correlated with training-induced left ventricular growth in ACE congenic rats.
Authors: Zalvidea, S., Py, G., Lambert, K., Jover, B., Dauzat, M., Le Gallais, D.
Source: Acta Physiologica. Oct2008, Vol. 194 Issue 2, p141-147. 7p. 3 Charts, 1 Graph.
Subjects: Angiotensin converting enzyme, Angiotensins, Genetic polymorphisms, Diagnostic ultrasonic imaging, Blood pressure, Cardiac imaging
Abstract: Aim: The aim of this study was to determine the influence of angiotensin-converting enzyme (ACE) genotype on left ventricular growth after endurance training, in ACE congenic rats with plasma ACE activity twice as high as the donor strain (LOU), thus mimicking the ACE I/D polymorphism observed in humans. Methods: LOU and congenic rats ( n = 12) were submitted to an endurance training on a treadmill for 7 weeks, while similar LOU and congenic rats ( n = 10) constituted the control groups. Blood pressure, skeletal muscle citrate synthase activity, plasma and left ventricular ACE activity were assessed, and echocardiography was performed before and after the training. Results: Angiotensin-converting enzyme plasmatic activity of congenic rats (188.2 ± 26.6 in controls and 187.1 ± 22.6 IU in trained rats respectively) was twofold that of the LOU strain (91.9 ± 23.3 in controls, and 88.3 ± 18.1 IU in trained rats respectively). After training, congenic and LOU rats showed a similar significant increase in citrate synthase activity ( P < 0.05), and in the left ventricular mass/body mass ratio × 103: 3.7 ± 0.3 and 3.6 ± 0.6 in the trained congenic and LOU groups, respectively, vs. 3.0 ± 0.1 and 2.9 ± 0.2 in the control congenic and LOU groups respectively ( P < 0.05). There was no significant correlation between ACE plasma activity and left ventricular mass in trained or untrained congenic rats. Conclusion: We conclude that training-induced left ventricular growth is not associated with plasma ACE activity in congenic rats. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: High plasmatic angiotensin-converting enzyme (ACE) activity is not correlated with training-induced left ventricular growth in ACE congenic rats.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Physiologica%22&quot;&gt;Acta Physiologica&lt;/searchLink&gt;. Oct2008, Vol. 194 Issue 2, p141-147. 7p. 3 Charts, 1 Graph.
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  Data: Aim: The aim of this study was to determine the influence of angiotensin-converting enzyme (ACE) genotype on left ventricular growth after endurance training, in ACE congenic rats with plasma ACE activity twice as high as the donor strain (LOU), thus mimicking the ACE I/D polymorphism observed in humans. Methods: LOU and congenic rats ( n = 12) were submitted to an endurance training on a treadmill for 7 weeks, while similar LOU and congenic rats ( n = 10) constituted the control groups. Blood pressure, skeletal muscle citrate synthase activity, plasma and left ventricular ACE activity were assessed, and echocardiography was performed before and after the training. Results: Angiotensin-converting enzyme plasmatic activity of congenic rats (188.2 &#177; 26.6 in controls and 187.1 &#177; 22.6 IU in trained rats respectively) was twofold that of the LOU strain (91.9 &#177; 23.3 in controls, and 88.3 &#177; 18.1 IU in trained rats respectively). After training, congenic and LOU rats showed a similar significant increase in citrate synthase activity ( P &lt; 0.05), and in the left ventricular mass/body mass ratio &#215; 103: 3.7 &#177; 0.3 and 3.6 &#177; 0.6 in the trained congenic and LOU groups, respectively, vs. 3.0 &#177; 0.1 and 2.9 &#177; 0.2 in the control congenic and LOU groups respectively ( P &lt; 0.05). There was no significant correlation between ACE plasma activity and left ventricular mass in trained or untrained congenic rats. Conclusion: We conclude that training-induced left ventricular growth is not associated with plasma ACE activity in congenic rats. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1748-1716.2008.01868.x
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        Text: English
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        PageCount: 7
        StartPage: 141
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      – SubjectFull: Angiotensin converting enzyme
        Type: general
      – SubjectFull: Angiotensins
        Type: general
      – SubjectFull: Genetic polymorphisms
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      – SubjectFull: Diagnostic ultrasonic imaging
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      – SubjectFull: Blood pressure
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      – SubjectFull: Cardiac imaging
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      – TitleFull: High plasmatic angiotensin-converting enzyme (ACE) activity is not correlated with training-induced left ventricular growth in ACE congenic rats.
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              Text: Oct2008
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